Canonical isoform: P28482-1 [UniProt]
Other possible isoforms:
P28482-2
HUGO gene symbols:
Protein name: Mitogen-activated protein kinase 1
Associated HotPTM clusters:
CPTAC:11200
PTM sites from various resources including CPTAC, PhosphoSitePlus and UniProtKB.
The TCGA PanCancer Atlas MC3 set is a collection of pancancer somatic mutations calls from all TCGA samples. More information can be found on MC3 project page.
COSMIC (the Catalogue Of Somatic Mutations In Cancer) is collection of somatic mutations in cancer with additional manual curation. More information can be found on COSMIC website.
(Only the canonical isoform P28482-1 is shown)
| Position | Residue | Category | PTM Type | Evidence (Manual/Automatic assertion) |
|---|---|---|---|---|
| 2 | A | Acetylation | N-acetylalanine |
Manual assertion based on experiment [ECO:0000269]
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
|
| 25 | Y | Phosphorylation | Phosphotyrosine |
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative Analysis of Signaling Networks across Differentially Embedded Tumors Highlights Interpatient Heterogeneity in Human Glioblastoma
|
| 29 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration.
Manual assertion based on experiment [ECO:0000269]
Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration.
|
| 30 | Y | Phosphorylation | Phosphotyrosine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
|
| 36 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 43 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 55 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 99 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
|
| 99 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
|
| 113 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 142 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics
|
| 151 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 153 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
|
| 164 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
|
| 164 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 181 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
A secreted tyrosine kinase acts in the extracellular environment.
Regulation of tamoxifen sensitivity by a PAK1–EBP1 signalling pathway in breast cancer
PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS
Analysis of Phosphotyrosine Signaling in Glioblastoma Identifies STAT5 as a Novel Downstream Target of ΔEGFR
Tyrosine Phosphorylation Profiling in FGF-2 Stimulated Human Embryonic Stem Cells
Survey of Activated FLT3 Signaling in Leukemia
Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin-Expressing Cells
Mel-18 Negatively Regulates INK4a/ARF-Independent Cell Cycle Progression via Akt Inactivation in Breast Cancer
Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
|
| 185 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Epidermal growth factor receptor signaling suppresses αvβ6 integrin and promotes periodontal inflammation and bone loss
The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells
The Prolyl Isomerase Pin1 Controls Lipopolysaccharide-Induced Priming of NADPH Oxidase in Human Neutrophils
Biased antagonism of CXCR4 avoids antagonist tolerance
Mechanisms for DNA‑damaging agent‑induced inactivation of ErbB2 and ErbB3 via the ERK and p38 signaling pathways
Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells
Phosphorylation of the C-Raf N Region Promotes Raf Dimerization
Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells
Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer
Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors
Interdependence of JAK-STAT and MAPK signaling pathways during EGF-mediated HTR-8/SVneo cell invasion
Comparison of Acalabrutinib, A Selective Bruton Tyrosine Kinase Inhibitor, with Ibrutinib in Chronic Lymphocytic Leukemia Cells
Gas6/AXL Signaling Regulates Self-Renewal of Chronic Myelogenous Leukemia Stem Cells by Stabilizing β-Catenin
CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency
Idelalisib Impacts Cell Growth through Inhibiting Translation-Regulatory Mechanisms in Mantle Cell Lymphoma
Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway
Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography
Evidence for Pro-angiogenic Functions of VEGF-Ax
Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways
Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling
Loss of MLCK leads to disruption of cell–cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling
A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation
KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway
Laminin-111 peptide C16 regulates invadopodia activity of malignant cells through β1 integrin, Src and ERK 1/2
Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
Proteogenomics connects somatic mutations to signalling in breast cancer
Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling
PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies
Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities
Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494
Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells
Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2
Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells
mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells
Role of Erk1/2 Signaling in the Regulation of Neutrophil Versus Monocyte Development in Response to G-CSF and M-CSF
Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells
EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function
Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient–Derived Xenograft Models
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Leupaxin stimulates adhesion and migration of prostate cancer cells through modulation of the phosphorylation status of the actin-binding protein caldesmon
ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion
A Lactate-Induced Response to Hypoxia
Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors
Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts
Phospho-STIM1 is a downstream effector that mediates the signaling triggered by IGF-1 in HEK293 cells
Structural assembly of the signaling competent ERK2–RSK1 heterodimeric protein kinase complex
PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester
MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1
Neurotrophin Signaling via TrkB and TrkC Receptors Promotes the Growth of Brain Tumor-initiating Cells
Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth
Functional Consequences of 17q21.31/WNT3-WNT9B Amplification in hPSCs with Respect to Neural Differentiation
Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction.
RasGRP3 regulates the migration of glioma cells via interaction with Arp3
Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance.
The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation
Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis
14-3-3 Proteins Buffer Intracellular Calcium Sensing Receptors to Constrain Signaling
Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells
Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells
Dimethylfumarate protects against TNF-α-induced secretion of inflammatory cytokines in human endothelial cells
Short-term high glucose exposure impairs insulin signaling in endothelial cells
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition
Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation
The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway
Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia
Angiogenin promotes tumoral growth and angiogenesis by regulating matrix metallopeptidase-2 expression via the ERK1/2 pathway
Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance
Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via the Lyn-PI3K/AKT pathway
Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion
Quantitative Analysis of Signaling Networks across Differentially Embedded Tumors Highlights Interpatient Heterogeneity in Human Glioblastoma
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
A secreted tyrosine kinase acts in the extracellular environment.
Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma
Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non–Small Cell Lung Cancer
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells
Adducin Is Required for Desmosomal Cohesion in Keratinocytes
Global Phosphoproteomic Profiling Reveals Distinct Signatures in B-Cell Non-Hodgkin Lymphomas
Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis
EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368
G-Protein–Coupled Receptor-2–Interacting Protein-1 Is Required for Endothelial Cell Directional Migration and Tumor Angiogenesis via Cortactin-Dependent Lamellipodia Formation
A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
Vascular Endothelial Tight Junctions and Barrier Function Are Disrupted by 15(S)-Hydroxyeicosatetraenoic Acid Partly via Protein Kinase Cϵ-mediated Zona Occludens-1 Phosphorylation at Threonine 770/772
Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)–ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration
Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
The known interactome of PTPIP51 in HaCaT cells—Inhibition of kinases and receptors
Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma
Quantification of Pancreatic Cancer Proteome and Phosphorylome: Indicates Molecular Events Likely Contributing to Cancer and Activity of Drug Targets
Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells
YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma
Phosphocaveolin-1 Enforces Tumor Growth and Chemoresistance in Rhabdomyosarcoma
Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins
Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y1086, c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity
Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1
pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner
p120 catenin is a key effector of a Ras-PKCɛ oncogenic signaling axis
Metformin Represses Drug-Induced Expression of CYP2B6 by Modulating the Constitutive Androstane Receptor Signaling
Estrogen protects SGC7901 cells from endoplasmic reticulum stress-induced apoptosis by the Akt pathway
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1
Design optimization and characterization of Her2/neu-targeted immunotoxins: comparative in vitro and in vivo efficacy studies
p38-Mediated phosphorylation of Eps15 endocytic adaptor protein
Casein Kinase 1ε Promotes Cell Proliferation by Regulating mRNA Translation
Inhibition of STIM1 phosphorylation underlies resveratrol-induced inhibition of store-operated calcium entry
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors
Tyrosine Phosphorylation of CD13 Regulates Inflammatory Cell–Cell Adhesion and Monocyte Trafficking
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)
Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells
Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1
Integrated proteomic analysis of post-translational modifications by serial enrichment
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines
Recruitment of Nox4 to a Plasma Membrane Scaffold Is Required for Localized Reactive Oxygen Species Generation and Sustained Src Activation in Response to Insulin-like Growth Factor-I
Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase Cϵ Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation
Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.
Phosphotyrosine Profiling of NSCLC Cells in Response to EGF and HGF Reveals Network Specific Mediators of Invasion
Mitogen-activated protein kinase modulates ethanol inhibition of cell adhesion mediated by the L1 neural cell adhesion molecule
A novelSOS1mutation in Costello/CFC syndrome affects signaling in both RAS and PI3K pathways
p38α phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles
cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.
Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway
CDK inhibitor p57Kip2 is downregulated by Akt during HER2-mediated tumorigenicity
Regulation of tamoxifen sensitivity by a PAK1–EBP1 signalling pathway in breast cancer
ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser777 Inhibits Signaling
Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Molecular Mechanisms and Modulation of Key Pathways Underlying the Synergistic Interaction of Sorafenib with Erlotinib in Non-Small-Cell-Lung Cancer (NSCLC) Cells
ERK Positive Feedback Regulates a Widespread Network of Tyrosine Phosphorylation Sites across Canonical T Cell Signaling and Actin Cytoskeletal Proteins in Jurkat T Cells
Quantitative Phosphoproteomic Analysis Identifies Activation of the RET and IGF-1R/IR Signaling Pathways in Neuroblastoma
Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors
Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop
Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin
Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587
Novel involvement of leukotriene B4 receptor 2 through ERK activation by PP2A down-regulation in leukotriene B4-induced keratin phosphorylation and reorganization of pancreatic cancer cells
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Molecular Characterization of EGFR and EGFRvIII Signaling Networks in Human Glioblastoma Tumor Xenografts
RSK2Ser227 at N-Terminal Kinase Domain Is a Potential Therapeutic Target for Multiple Myeloma
Extracellular Signal-regulated Kinase 2 (ERK2) Mediates Phosphorylation and Inactivation of Nuclear Interaction Partner of Anaplastic Lymphoma Kinase (NIPA) at G2/M*
The TLR7/8 Agonist CL097 PrimesN-Formyl-Methionyl-Leucyl-Phenylalanine–Stimulated NADPH Oxidase Activation in Human Neutrophils: Critical Role of p47phox Phosphorylation and the Proline Isomerase Pin1
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Coregulation of Multiple Signaling Mechanisms in pp60v-Src-Induced Closure of Cx43 Gap Junction Channels
Phosphoproteomic Analysis of Leukemia Cells under Basal and Drug-treated Conditions Identifies Markers of Kinase Pathway Activation and Mechanisms of Resistance*
Time-Resolved Quantitative Phosphoproteomics: New Insights into Angiotensin-(1–7) Signaling Networks in Human Endothelial Cells
c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1
Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors
Lyn Kinase Mediates Cell Motility and Tumor Growth in EGFRvIII-Expressing Head and Neck Cancer
PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS
Quantitative Phosphoproteomic Analysis Reveals a Role for Serine and Threonine Kinases in the Cytoskeletal Reorganization in Early T Cell Receptor Activation in Human Primary T Cells
Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Intestinal Cell Kinase (ICK) Promotes Activation of mTOR Complex 1 (mTORC1) through Phosphorylation of Raptor Thr-908*
P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation
Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation
Inhibition of Insulin Signaling in Endothelial Cells by Protein Kinase C-induced Phosphorylation of p85 Subunit of Phosphatidylinositol 3-Kinase (PI3K)*
Protein-tyrosine Kinase 6 Promotes Peripheral Adhesion Complex Formation and Cell Migration by Phosphorylating p130 CRK-associated Substrate*
Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2.
ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity
Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells
Phosphorylation of serine 21 modulates the proliferation inhibitory more than the differentiation inducing effects of C/EBPα in K562 cells
Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation
Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor
Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia
Glabridin Inhibits Migration, Invasion, and Angiogenesis of Human Non–Small Cell Lung Cancer A549 Cells by Inhibiting the FAK/Rho Signaling Pathway
A Novel Kinase Inhibitor, INCB28060, Blocks c-MET–Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3
Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling
Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways
Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells
Importance of Domain Closure for the Autoactivation of ERK2
Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.
A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction
Involvement of Protein Kinase Cδ/Extracellular Signal-regulated Kinase/Poly(ADP-ribose) Polymerase-1 (PARP-1) Signaling Pathway in Histamine-induced Up-regulation of Histamine H1 Receptor Gene Expression in HeLa Cells
Oncogenic role of EAPII in lung cancer development and its activation of the MAPK–ERK pathway
Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation
Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer
HGF-independent potentiation of EGFR action by c-Met
Distinct Phosphorylation Sites on the 2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of -Arrestin
Processive phosphorylation of ERK MAP kinase in mammalian cells
VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation
Phosphorylation of Histone H2B Serine 32 Is Linked to Cell Transformation
Aberrant ribosome biogenesis activates c-Myc and ASK1 pathways resulting in p53-dependent G1 arrest
A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling
Btk is a positive regulator in the TREM-1/DAP12 signaling pathway.
Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells
Quantitative Phospho-Proteomic Profiling of Hepatocyte Growth Factor (HGF)-MET Signaling in Colorectal Cancer
Combination of PI3K/mTOR Inhibitors: Antitumor Activity and Molecular Correlates
Bim Protein Degradation Contributes to Cisplatin Resistance
cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway
PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis.
Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition
B7-H2 Is a Costimulatory Ligand for CD28 in Human
Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer
Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
Phosphomimetic Substitution of Heterogeneous Nuclear Ribonucleoprotein A1 at Serine 199 Abolishes AKT-dependent Internal Ribosome Entry Site-transacting Factor (ITAF) Function via Effects on Strand Annealing and Results in Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitor Sensitivity
Receptor-type Protein Tyrosine Phosphatase β (RPTP-β) Directly Dephosphorylates and Regulates Hepatocyte Growth Factor Receptor (HGFR/Met) Function
ERK and PDE4 cooperate to induce RAF isoform switching in melanoma
Transient PI3K Inhibition Induces Apoptosis and Overcomes HGF-Mediated Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer
A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions
Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
Tyrosine kinase-independent activation of extracellular-regulated kinase (ERK) 1/2 by the insulin-like growth factor-1 receptor
Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells: implication of EPCR, noncanonical NF-κB, and ERK1/2 MAP kinases
ERK1 and ERK2 are involved in recruitment and maturation of human mesenchymal stem cells induced to adipogenic differentiation
SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex.
Analysis of Phosphotyrosine Signaling in Glioblastoma Identifies STAT5 as a Novel Downstream Target of ΔEGFR
Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition
High dose human insulin and insulin glargine promote T24 bladder cancer cell proliferation via PI3K-independent activation of Akt
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells
SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein
Survey of Tyrosine Kinase Signaling Reveals ROS Kinase Fusions in Human Cholangiocarcinoma
Tyrosine Phosphorylation Profiling in FGF-2 Stimulated Human Embryonic Stem Cells
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Phasic Phosphorylation of Caldesmon and ERK 1/2 during Contractions in Human Myometrium
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment
Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma
Cell Cycle Phase Regulates Glucocorticoid Receptor Function
Resveratrol Inhibits Growth of Orthotopic Pancreatic Tumors through Activation of FOXO Transcription Factors
Survey of Activated FLT3 Signaling in Leukemia
Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes
Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death
Serine phosphorylation of NPM-ALK, which is dependent on the auto-activation of the kinase activation loop, contributes to its oncogenic potential
Inhibition of Grb2 expression demonstrates an important role in BCR–ABL-mediated MAPK activation and transformation of primary human hematopoietic cells
Annexin‐1 signals mitogen‐stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2
IL-6 Trans-Signaling in Formation and Progression of Malignant Ascites in Ovarian Cancer
HER1 Signaling Mediates Extravillous Trophoblast Differentiation in Humans1
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.
Alternative ERK5 regulation by phosphorylation during the cell cycle
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor
IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines
Profiling Y561-Dependent and -Independent Substrates of CSF-1R in Epithelial Cells
p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients
A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage
Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling
Quantitative Phosphoproteomics of Proteasome Inhibition in Multiple Myeloma Cells
Cross-talk between Serine/Threonine Protein Phosphatase 2A and Protein Tyrosine Phosphatase 1B Regulates Src Activation and Adhesion of Integrin αIIbβ3 to Fibrinogen
Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry
Paxillin Regulates Androgen- and Epidermal Growth Factor-induced MAPK Signaling and Cell Proliferation in Prostate Cancer Cells*
Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
Global phosphorylation analysis of -arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)
Regulation of Prostate Cancer Cell Survival by Protein Kinase C∈ Involves Bad Phosphorylation and Modulation of the TNFα/JNK Pathway
Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance
A stress survival response in retinal cells mediated through inhibition of the serine / threonine phosphatase PP2A
The Combination of Multiple Receptor Tyrosine Kinase Inhibitor and Mammalian Target of Rapamycin Inhibitor Overcomes Erlotinib Resistance in Lung Cancer Cell Lines through c-Met Inhibition
Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
SIRPα1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration
Suppressor of Cytokine Signaling 2 Regulates IL-15–Primed Human NK Cell Function via Control of Phosphorylated Pyk2
Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
Comprehensive Mapping of the Human Kinome to Epidermal Growth Factor Receptor Signaling*
Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta.
Priming of Signal Transducer and Activator of Transcription Proteins for Cytokine-Triggered Polyubiquitylation and Degradation by the A2A Adenosine Receptor
Quantitative Site-specific Phosphorylation Dynamics of Human Protein Kinases during Mitotic Progression
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
Prostaglandin F2α Represses IGF-I-Stimulated IRS1/Phosphatidylinositol-3-Kinase/AKT Signaling in the Corpus Luteum: Role of ERK and P70 Ribosomal S6 Kinase
Tau Potentiates Nerve Growth Factor-induced Mitogen-activated Protein Kinase Signaling and Neurite Initiation without a Requirement for Microtubule Binding*
Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis
An Integrated Phosphoproteomics Work Flow Reveals Extensive Network Regulation in Early Lysophosphatidic Acid Signaling
Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis
Proteinase‐activated receptors induce interleukin‐8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation
Protein kinase Cɛ mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2)
Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.
IGFBP7 Is Not Required for B-RAF-Induced Melanocyte Senescence
Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells
Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death
Activation of the Integrin Effector Kinase Focal Adhesion Kinase in Cancer Cells Is Regulated by Crosstalk between Protein Kinase C and the PDZ Adapter Protein mda-9/Syntenin
MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
IAP Regulation of Metastasis
A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells
Sunitinib Induces Apoptosis and Growth Arrest of Medulloblastoma Tumor Cells by Inhibiting STAT3 and AKT Signaling Pathways
Modulation of Akt and ERK1/2 Pathways by Resveratrol in Chronic Myelogenous Leukemia (CML) Cells Results in the Downregulation of Hsp70
Phospholipase D1 Mediates AMP-Activated Protein Kinase Signaling for Glucose Uptake
Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids
A Loss-of-Function Screen Reveals Ras- and Raf-Independent MEK-ERK Signaling During Chlamydia trachomatis Infection
Rapamycin Inhibits IGF-1 Stimulated Cell Motility through PP2A Pathway
Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin21-157
Distinct Changes in cAMP and Extracellular Signal-Regulated Protein Kinase Signalling in L-DOPA-Induced Dyskinesia
Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells
Signal Transducers and Activators of Transcription-3 Binding to the Fibroblast Growth Factor Receptor Is Activated by Receptor Amplification
Extracellular Signal-Regulated Kinase 8–Mediated c-Jun Phosphorylation Increases Tumorigenesis of Human Colon Cancer
Sp1/NFκB/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia
Role of Epidermal Growth Factor Receptor Degradation in Cisplatin-Induced Cytotoxicity in Head and Neck Cancer
Identification of activated Tnk1 kinase in Hodgkin's lymphoma
Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor
Copine-III interacts with ErbB2 and promotes tumor cell migration.
mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm
Basic Design of MRM Assays for Peptide Quantification
C/EBP expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway
Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway
c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells
mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation
Overexpression of Phospho-eIF4E Is Associated with Survival through AKT Pathway in Non-Small Cell Lung Cancer
Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor α and its phosphorylation at serine 305
Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions
Cannabinoid Receptor Type 1- and 2-mediated Increase in Cyclic AMP Inhibits T Cell Receptor-triggered Signaling
Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin-Expressing Cells
Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics*
Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis
EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin
Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition
In vivoPhosphoproteome of Human Skeletal Muscle Revealed by Phosphopeptide Enrichment and HPLC−ESI−MS/MS
An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.
A New Approach for Quantitative Phosphoproteomic Dissection of Signaling Pathways Applied to T Cell Receptor Activation*
c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential
Dependence of EGF-Induced Increases in Corneal Epithelial Proliferation and Migration on GSK-3 Inactivation
An Extensive Survey of Tyrosine Phosphorylation Revealing New Sites in Human Mammary Epithelial Cells
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.
Large-scale proteomics analysis of the human kinome.
Prolactin and estradiol utilize distinct mechanisms to increase serine-118 phosphorylation and decrease levels of estrogen receptor α in T47D breast cancer cells
The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R
Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration
Raptor Binds the SAIN (Shc and IRS-1 NPXY Binding) Domain of Insulin Receptor Substrate-1 (IRS-1) and Regulates the Phosphorylation of IRS-1 at Ser-636/639 by mTOR
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.
Mechanism of Activation and Functional Role of Protein Kinase Cη in Human Platelets
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration.
Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets
Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment
Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling.
MEK1 Binds Directly to βArrestin1, Influencing Both Its Phosphorylation by ERK and the Timing of Its Isoprenaline-stimulated Internalization
Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.
Short-Term Overeating Induces Insulin Resistance in Fat Cells in Lean Human Subjects
EphA2 Engages Git1 to Suppress Arf6 Activity Modulating Epithelial Cell–Cell Contacts
CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells
Activation of the unliganded estrogen receptor by prolactin in breast cancer cells
S6 Kinase 1 Regulates Estrogen Receptor α in Control of Breast Cancer Cell Proliferation
Tectoridin, a poor ligand of estrogen receptor α, exerts its estrogenic effects via an ERK-dependent pathway
Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor
Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation
Mechanisms of Sleep-Dependent Consolidation of Cortical Plasticity
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.
The Lysyl Oxidase Pro-peptide Attenuates Fibronectin-mediated Activation of Focal Adhesion Kinase and p130Cas in Breast Cancer Cells
Silibinin Suppresses Growth of Human Prostate Carcinoma PC-3 Orthotopic Xenograft via Activation of Extracellular Signal-Regulated Kinase 1/2 and Inhibition of Signal Transducers and Activators of Transcription Signaling
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway.
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy.
ERK1/2 Mediate Wounding- and G-protein-Coupled Receptor Ligands-Induced EGFR Activation via Regulating ADAM17 and HB-EGF Shedding
T Cell Adhesion Primes Antigen Receptor-Induced Calcium Responses through a Transient Rise in Adenosine 3′,5′-Cyclic Monophosphate
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation
A Concerted Kinase Interplay Identifies PPARγ as a Molecular Target of Ghrelin Signaling in Macrophages
Phosphatase-Dependent Regulation of Epithelial Mitogen-Activated Protein Kinase Responses to Toxin-Induced Membrane Pores
Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells
Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha
Epidermal growth factor receptor mutations in non-small cell lung cancer influence downstream Akt, MAPK and Stat3 signaling
Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene
Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase.
Enzastaurin, an inhibitor of PKCβ, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells
Follistatin-like 1, a Secreted Muscle Protein, Promotes Endothelial Cell Function and Revascularization in Ischemic Tissue through a Nitric-oxide Synthase-dependent Mechanism
Characterization of Ser338 Phosphorylation for Raf-1 Activation
Cytokine-Induced Signaling Networks Prioritize Dynamic Range over Signal Strength
MLK3 Limits Activated Gαq Signaling to Rho by Binding to p63RhoGEF
WNK2 modulates MEK1 activity through the Rho GTPase pathway.
Phosphorylation of p27Kip1 Regulates Assembly and Activation of Cyclin D1-Cdk4
Identification and characterization of a general nuclear translocation signal in signaling proteins.
Essential Role of ERK Dimers in the Activation of Cytoplasmic but Not Nuclear Substrates by ERK-Scaffold Complexes
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
A quantitative atlas of mitotic phosphorylation.
siRNA-Mediated Reduction of Inhibitor of Nuclear Factor- B Kinase Prevents Tumor Necrosis Factor- -Induced Insulin Resistance in Human Skeletal Muscle
Phosphorylated Heat Shock Protein 27 Represses Growth of Hepatocellular Carcinoma via Inhibition of Extracellular Signal-regulated Kinase
γ-Irradiation–Induced DNA Damage Checkpoint Activation Involves Feedback Regulation between Extracellular Signal-Regulated Kinase 1/2 and BRCA1
NF-κB-dependent Transcriptional Activation in Lung Carcinoma Cells by Farnesol Involves p65/RelA(Ser276) Phosphorylation via the MEK-MSK1 Signaling Pathway
Mel-18 Negatively Regulates INK4a/ARF-Independent Cell Cycle Progression via Akt Inactivation in Breast Cancer
Inhibition of STAT3Tyr705 Phosphorylation by Smad4 Suppresses Transforming Growth Factor β–Mediated Invasion and Metastasis in Pancreatic Cancer Cells
Mutant B-RAF mediates resistance to anoikis via Bad and Bim
Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2.
Akt3 and Mutant V600EB-Raf Cooperate to Promote Early Melanoma Development
A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Interaction between ERK and GSK3β Mediates Basic Fibroblast Growth Factor-induced Apoptosis in SK-N-MC Neuroblastoma Cells
The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK
Transcriptional Activity of the ΔNp63 Promoter Is Regulated by STAT3
Enzastaurin, a Protein Kinase Cβ Inhibitor, Suppresses Signaling through the Ribosomal S6 Kinase and Bad Pathways and Induces Apoptosis in Human Gastric Cancer Cells
Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
mTORC1 Signaling Can Regulate Growth Factor Activation of p44/42 Mitogen-activated Protein Kinases through Protein Phosphatase 2A
PINCH-1 Regulates the ERK-Bim Pathway and Contributes to Apoptosis Resistance in Cancer Cells
Paxillin Phosphorylation Controls Invadopodia/Podosomes Spatiotemporal Organization
Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7.
Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt
A Nurr1 point mutant, implicated in Parkinson’s disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription
AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation
Signaling networks assembled by oncogenic EGFR and c-Met
Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating p27Kip1
Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
Altered PI3-Kinase/Akt Signalling in Skeletal Muscle of Young Men with Low Birth Weight
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells
Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage.
Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Cyclin-Dependent Kinase-3–Mediated c-Jun Phosphorylation at Ser63 and Ser73 Enhances Cell Transformation
Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells
A new mechanism for the regulation of Gab1 recruitment to the plasma membrane
Stereochemistry of an Agonist Determines Coupling Preference of β2-Adrenoceptor to Different G Proteins in Cardiomyocytes
Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
NF-κB Signaling, Elastase Localization, and Phagocytosis Differ in HIV-1 Permissive and Nonpermissive U937 Clones
The SH3 Domain of Lck Modulates T-Cell Receptor-Dependent Activation of Extracellular Signal-Regulated Kinase through Activation of Raf-1
Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
Critical Role of the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase-3β Signaling Pathway in Recovery from Anthrax Lethal Toxin-induced Cell Cycle Arrest and MEK Cleavage in Macrophages
TNFR1 and TNFR2 Signaling Interplay in Cardiac Myocytes
Targeting of FAK Ser910 by ERK5 and PP1δ in non-stimulated and phorbol ester-stimulated cells
Epinephrine Regulation of the Endothelial Nitric-oxide Synthase
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis
Sp3-Mediated VEGF regulation is dependent on phosphorylation by extra-cellular signals regulated kinases (Erk)
SHP-2 is required for the maintenance of cardiac progenitors
Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress.
A Functional Serine 118 Phosphorylation Site in Estrogen Receptor-α Is Required for Down-Regulation of Gene Expression by 17β-Estradiol and 4-Hydroxytamoxifen
EF24 Induces G2/M Arrest and Apoptosis in Cisplatin-resistant Human Ovarian Cancer Cells by Increasing PTEN Expression
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells
Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.
Ribosomal S6 Kinase 2 Is a Key Regulator in Tumor Promoter–Induced Cell Transformation
Regulation of α1-Adrenoceptor-Mediated Contractions of the Uterine Artery by Protein Kinase C: Role of the Thick- and Thin-Filament Regulatory Pathways
Characterization of the activity of human MAP kinase-interacting kinase Mnk1b
FGFR3 Activates RSK2 to Mediate Hematopoietic Transformation through Tyrosine Phosphorylation of RSK2 and Activation of the MEK/ERK Pathway
Ouabain stimulates protein kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway
Possible Role of 5′AMP-Activated Protein Kinase in the Metformin-Mediated Arrest of Bovine Oocytes at the Germinal Vesicle Stage During In Vitro Maturation1
Dimethylfumarate Specifically Inhibits the Mitogen and Stress-Activated Kinases 1 and 2 (MSK1/2): Possible Role for its Anti-Psoriatic Effect
Pressure induces loss of gap junction communication and redistribution of connexin 43 in astrocytes
Identification of S664 TSC2 Phosphorylation as a Marker for Extracellular Signal-Regulated Kinase–Mediated mTOR Activation in Tuberous Sclerosis and Human Cancer
Isoobtusilactone A Induces Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species/Apoptosis Signal-Regulating Kinase 1 Signaling Pathway in Human Breast Cancer Cells
Structure-Function Studies of Allosteric Agonism at M2Muscarinic Acetylcholine Receptors
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
Irradiation-induced G2/M checkpoint response requires ERK1/2 activation
Differential phosphorylation of NG2 proteoglycan by ERK and PKCα helps balance cell proliferation and migration
Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity
Aspirin-Triggered Lipoxins Override the Apoptosis-Delaying Action of Serum Amyloid A in Human Neutrophils: A Novel Mechanism for Resolution of Inflammation
Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells
Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2α (Ser51)
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
Transactivation of the Epidermal Growth Factor Receptor by Formylpeptide Receptor Exacerbates the Malignant Behavior of Human Glioblastoma Cells
Ubiquitin-Independent Proteasomal Degradation of Fra-1 Is Antagonized by Erk1/2 Pathway-Mediated Phosphorylation of a Unique C-Terminal Destabilizer
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling.
Histone Deacetylase Inhibitor Trichostatin A Sustains Sodium Pervanadate-induced NF-κB Activation by Delaying IκBα mRNA Resynthesis
EGFR-T790M Is a Rare Lung Cancer Susceptibility Allele with Enhanced Kinase Activity
Profiling signaling polarity in chemotactic cells
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.
Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells
Tissue Kallikrein Reverses Insulin Resistance and Attenuates Nephropathy in Diabetic Rats by Activation of Phosphatidylinositol 3-Kinase/Protein Kinase B and Adenosine 5′-Monophosphate-Activated Protein Kinase Signaling Pathways
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells
Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage.
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks
Bcl10 Controls TCR- and FcγR-Induced Actin Polymerization
CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor
The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms
Direct Binding of PP2A to Sprouty2 and Phosphorylation Changes Are a Prerequisite for ERK Inhibition Downstream of Fibroblast Growth Factor Receptor Stimulation
Mitogen-activated Protein Kinase-dependent Activation of the Na+/H+ Exchanger Is Mediated through Phosphorylation of Amino Acids Ser770 and Ser771
Ras/ERK1/2-mediated STAT3 Ser727 Phosphorylation by Familial Medullary Thyroid Carcinoma-associated RET Mutants Induces Full Activation of STAT3 and Is Required for c-fos Promoter Activation, Cell Mitogenicity, and Transformation
Proteomics Analysis of Protein Kinases by Target Class-selective Prefractionation and Tandem Mass Spectrometry
Effects of Metformin on Bovine Granulosa Cells Steroidogenesis: Possible Involvement of Adenosine 5′ Monophosphate-Activated Protein Kinase (AMPK)1
Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells
Interleukin-6 Impairs the Insulin Signaling Pathway, Promoting Production of Nitric Oxide in Human Umbilical Vein Endothelial Cells
Inhibition of B56-containing Protein Phosphatase 2As by the Early Response Gene IEX-1 Leads to Control of Akt Activity
Withaferin A Strongly Elicits IκB Kinase β Hyperphosphorylation Concomitant with Potent Inhibition of Its Kinase Activity*
Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker
Extracellular Signal-Related Kinase Positively Regulates Ataxia Telangiectasia Mutated, Homologous Recombination Repair, and the DNA Damage Response
Lapatinib Antitumor Activity Is Not Dependent upon Phosphatase and Tensin Homologue Deleted on Chromosome 10 in ErbB2-Overexpressing Breast Cancers
Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB.
Threonine phosphorylation of integrin β3 in calyculin A-treated platelets is selectively sensitive to 5′-iodotubercidin
Vascular Endothelial Growth Factor Receptor 2 Plays a Role in the Activation of Aortic Endothelial Cells by Oxidized Phospholipids
Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth.
Inactivation of Myocardin and p16 during Malignant Transformation Contributes to a Differentiation Defect
A Key Role of Leptin in the Control of Regulatory T Cell Proliferation
PRAK is essential for ras-induced senescence and tumor suppression.
Activation of Akt Predicts Poor Outcome in Neuroblastoma
Repetitive Deformation Activates Focal Adhesion Kinase and ERK Mitogenic Signals in Human Caco-2 Intestinal Epithelial Cells through Src and Rac1
Ca2+-Stimulated Adenylyl Cyclases Regulate ERK-Dependent Activation of MSK1 during Fear Conditioning
RET/Papillary Thyroid Carcinoma Oncogenic Signaling through the Rap1 Small GTPase
Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation
Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling
ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells
Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing
The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway.
Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3
Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis
Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress
FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells
Chemokine CXCL12 Induces Binding of Ferritin Heavy Chain to the Chemokine Receptor CXCR4, Alters CXCR4 Signaling, and Induces Phosphorylation and Nuclear Translocation of Ferritin Heavy Chain
TLR4-Dependent NF-κB Activation and Mitogen- and Stress-Activated Protein Kinase 1-Triggered Phosphorylation Events Are Central toHelicobacter pyloriPeptidyl Prolylcis-,trans-Isomerase (HP0175)-Mediated Induction of IL-6 Release from Macrophages
A negative feedback signaling network underlies oncogene-induced senescence
A novel cellular survival factor – the B2 subunit of vacuolar H+-ATPase inhibits apoptosis
Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase Cβ
Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer
Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells
An Inherent Role of Integrin-Linked Kinase-Estrogen Receptor α Interaction in Cell Migration
Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise
PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells
S-Glutathiolation of p21ras by Peroxynitrite Mediates Endothelial Insulin Resistance Caused by Oxidized Low-Density Lipoprotein
A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenes
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
Estrogen-Induced Activation of Mammalian Target of Rapamycin Is Mediated via Tuberin and the Small GTPase Ras Homologue Enriched in Brain
Regulation of androgen receptor activity by tyrosine phosphorylation.
CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex
Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells
Epidermal Growth Factor Protects Prostate Cancer Cells from Apoptosis by Inducing BAD Phosphorylation via Redundant Signaling Pathways
The Isoflavone Equol Mediates Rapid Vascular Relaxation
Suppression of NF-κB Activation by Entamoeba histolytica in Intestinal Epithelial Cells Is Mediated by Heat Shock Protein 27
Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux® ) results in paradox phosphorylation of tyrosine 1173 in the receptor
Rheb Inhibits C-Raf Activity and B-Raf/C-Raf Heterodimerization
Integrin αVβ3 contains a receptor site for resveratrol
Δ9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
Raf Kinase Inhibitory Protein Regulates Aurora B Kinase and the Spindle Checkpoint
CXCR4 Physically Associates with the T Cell Receptor to Signal in T Cells
Role of c-Src in Human MCF7 Breast Cancer Cell Tumorigenesis
Epidermal growth factor and serum activate distinct pathways to inhibit the BH3 only protein BAD in prostate carcinoma LNCaP cells
Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation
Activation of Gab1 in pancreatic acinar cells: Effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules
Muc4–ErbB2 Complex Formation and Signaling in Polarized CACO-2 Epithelial Cells Indicate That Muc4 Acts as an Unorthodox Ligand for ErbB2
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
Heat Shock Protein 25 or Inducible Heat Shock Protein 70 Activates Heat Shock Factor 1
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.
The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.
Elevated Expression of Mitogen-Activated Protein Kinase Phosphatase 3 in Breast Tumors: A Mechanism of Tamoxifen Resistance
Attenuation of Peroxisome Proliferator-activated Receptor γ (PPARγ) Mediates Gastrin-stimulated Colorectal Cancer Cell Proliferation
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt
Prognostic Significance of Activated AKT Expression in Soft-Tissue Sarcoma
Activation Function-1 Domain of Estrogen Receptor Regulates the Agonistic and Antagonistic Actions of Tamoxifen
Interaction with Grb14 results in site‐specific regulation of tyrosine phosphorylation of the insulin receptor
Dehydroepiandrosterone Mimics Acute Actions of Insulin to Stimulate Production of Both Nitric Oxide and Endothelin 1 via Distinct Phosphatidylinositol 3-Kinase- and Mitogen-Activated Protein Kinase-Dependent Pathways in Vascular Endothelium
Cyclooxygenase-2 Induction and Prostacyclin Release by Protease-activated Receptors in Endothelial Cells Require Cooperation between Mitogen-activated Protein Kinase and NF-κB Pathways
Basic Fibroblast Growth Factor Protects against Rotenone-Induced Dopaminergic Cell Death through Activation of Extracellular Signal-Regulated Kinases 1/2 and Phosphatidylinositol-3 Kinase Pathways
A Specific Mechanomodulatory Role for p38 MAPK in Embryonic Joint Articular Surface Cell MEK-ERK Pathway Regulation
Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.
Simultaneous Inhibition of PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial Dysfunction and Apoptosis in Acute Myelogenous Leukemia
p38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-α induced endothelial apoptosis
Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions
Oncostatin M Receptor-mediated Signal Transduction Is Negatively Regulated by SOCS3 through a Receptor Tyrosine-independent Mechanism
Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle
Quantitative Analysis of Phosphotyrosine Signaling Networks Triggered by CD3 and CD28 Costimulation in Jurkat Cells
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
IRS-1 Serine Phosphorylation and Insulin Resistance in Skeletal Muscle From Pancreas Transplant Recipients
Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells
Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
c-Myc Phosphorylation Is Required for Cellular Response to Oxidative Stress
Rac1 Modulates Sphingosine 1-Phosphate-mediated Activation of Phosphoinositide 3-Kinase/Akt Signaling Pathways in Vascular Endothelial Cells
Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation
The Raf Inhibitor BAY 43-9006 (Sorafenib) Induces Caspase-Independent Apoptosis in Melanoma Cells
Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.
The Inositol Polyphosphate 5-Phosphatase, PIPP, Is a Novel Regulator of Phosphoinositide 3-Kinase-dependent Neurite Elongation
Selective Repression of Low-Density Lipoprotein Receptor Expression by SP600125: Coupling of Histone H3-Ser10 Phosphorylation and Sp1 Occupancy
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
Oncostatin M-induced activation of stress-activated MAP kinases depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases
ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis
Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases
A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury
Genistein-induced neuronal differentiation is associated with activation of extracellular signal-regulated kinases and upregulation of p21 and N-cadherin
Bone Morphogenetic Protein-2–Induced Transformation Involves the Activation of Mammalian Target of Rapamycin
Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways.
A Positive Feedback Loop between Glycogen Synthase Kinase 3β and Protein Phosphatase 1 after Stimulation of NR2B NMDA Receptors in Forebrain Neurons
Features of the Catalytic Domains and C Termini of the MAPK Signal-integrating Kinases Mnk1 and Mnk2 Determine Their Differing Activities and Regulatory Properties
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors.
Phosphotyrosine Binding-Mediated Oligomerization of Downstream of Tyrosine Kinase (Dok)-1 and Dok-2 Is Involved in CD2-Induced Dok Phosphorylation
Tyrosine Phosphorylation of Caveolin 1 by Oxidative Stress Is Reversible and Dependent on the c-src Tyrosine Kinase but Not Mitogen-Activated Protein Kinase Pathways in Placental Artery Endothelial Cells1
Grb2 negatively regulates epidermal growth factor-induced phospholipase C-γ1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-γ1
Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.
Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1
Suppression of Urokinase Expression and Invasion by a Soybean Kunitz Trypsin Inhibitor Are Mediated through Inhibition of Src-dependent Signaling Pathways
The Platelet-derived Growth Factor Receptor-β Phosphorylates and Activates G Protein-coupled Receptor Kinase-2
Sprouty-2 Overexpression in C2C12 Cells Confers Myogenic Differentiation Properties in the Presence of FGF2
Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling
The Role of Protein-tyrosine Phosphatase 1B in Integrin Signaling
PKC-induced ERK1/2 interactions and downstream effectors in ovine cerebral arteries
The Pro33 Isoform of Integrin β3 Enhances Outside-in Signaling in Human Platelets by Regulating the Activation of Serine/Threonine Phosphatases
Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death.
Raf-1 Serine 338 Phosphorylation Plays a Key Role in Adhesion-Dependent Activation of Extracellular Signal-Regulated Kinase by Epidermal Growth Factor
The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase Phosphatase 1 Directs Nuclear Targeting and Serum Response Element Transcriptional Regulation
Transforming Growth Factor β (TGF-β)-Smad Target Gene Protein Tyrosine Phosphatase Receptor Type Kappa Is Required for TGF-β Function
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
Identification of a DEF-type Docking Domain for Extracellular Signal-regulated Kinases 1/2 That Directs Phosphorylation and Turnover of the BH3-only Protein BimEL
Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells.
The Role of Growth Factor Receptor Pathways in Human Breast Cancer Cells Adapted to Long-term Estrogen Deprivation
Dok-R Mediates Attenuation of Epidermal Growth Factor-Dependent Mitogen-Activated Protein Kinase and Akt Activation through Processive Recruitment of c-Src and Csk
The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.
Phosphotyrosine Signaling Networks in Epidermal Growth Factor Receptor Overexpressing Squamous Carcinoma Cells
Insulin-Like Growth Factor 1 Inhibits Extracellular Signal-Regulated Kinase to Promote Neuronal Survival via the Phosphatidylinositol 3-Kinase/Protein Kinase A/c-Raf Pathway
Modulation of Survival Signaling Pathways and Persistence of the Genotoxic Stress as a Basis for the Synergistic Interaction between the Atypical Retinoid ST1926 and the Epidermal Growth Factor Receptor Inhibitor ZD1839
Phosphorylation of Carboxyl-terminal Tyrosines Modulates the Specificity of Sprouty-2 Inhibition of Different Signaling Pathways
Angiopoietin-1 Promotes Cardiac and Skeletal Myocyte Survival Through Integrins
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
Inhibition of Integrin-Linked Kinase by a Selective Small Molecule Inhibitor, QLT0254, Inhibits the PI3K/PKB/mTOR, Stat3, and FKHR Pathways and Tumor Growth, and Enhances Gemcitabine-Induced Apoptosis in Human Orthotopic Primary Pancreatic Cancer Xenografts
c-Jun N-Terminal Kinase Contributes to Aberrant Retinoid Signaling in Lung Cancer Cells by Phosphorylating and Inducing Proteasomal Degradation of Retinoic Acid Receptor α
Disruption of the Shc/Grb2 Complex during Abelson Virus Transformation Affects Proliferation, but Not Apoptosis
Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
Regulation of chemotaxis by the cytoplasmic domain of tissue factor
Prolactin-Regulated Tyrosine Hydroxylase Activity and Messenger Ribonucleic Acid Expression in Mediobasal Hypothalamic Cultures: The Differential Role of Specific Protein Kinases
Activation of focal adhesion kinase in human lung cancer cells involves multiple and potentially parallel signaling events
Src Family Kinase Inhibitors Block Amphiregulin-Mediated Autocrine ErbB Signaling in Normal Human Keratinocytes
Connective Tissue Growth Factor CCN2 Interacts with and Activates the Tyrosine Kinase Receptor TrkA
17β-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo
Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites
Activation and translocation of PKCδ is necessary for VEGF-induced ERK activation through KDR in HEK293T cells
Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
Apelin (65‐77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells
Protein microarrays for multiplex analysis of signal transduction pathways
SHP-2-Dependent Mitogen-Activated Protein Kinase Activation Regulates EGFRvIII but not Wild-Type Epidermal Growth Factor Receptor Phosphorylation and Glioblastoma Cell Survival
Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle
The Role of Rho Kinase and Extracellular Regulated Kinase-Mitogen-Activated Protein Kinase in α2-Adrenoceptor-Mediated Vasoconstriction in the Porcine Palmar Lateral Vein
Regulation of hormone-sensitive lipase activity and Ser563and Ser565phosphorylation in human skeletal muscle during exercise
Proteomic Identification of Bcl2-associated Athanogene 2 as a Novel MAPK-activated Protein Kinase 2 Substrate
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.
T-cell receptor–induced phosphorylation of the ζ chain is efficiently promoted by ZAP-70 but not Syk
Differential Pathways of Angiotensin II-Induced Extracellularly Regulated Kinase 1/2 Phosphorylation in Specific Cell Types: Role of Heparin-Binding Epidermal Growth Factor
Down-regulation of WW Domain-containing Oxidoreductase Induces Tau Phosphorylation in Vitro
Involvement of protein kinase C-alpha and -epsilon in extracellular Ca2+ signalling mediated by the calcium sensing receptor
Thyroid Hormone Causes Mitogen-Activated Protein Kinase-Dependent Phosphorylation of the Nuclear Estrogen Receptor
Extracellular pressure stimulates macrophage phagocytosis by inhibiting a pathway involving FAK and ERK
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
Tyrosine Phosphorylation of Sprouty Proteins Regulates Their Ability to Inhibit Growth Factor Signaling: A Dual Feedback Loop
Extracellular Regulated Kinase/Mitogen Activated Protein Kinase Is Up-regulated in Pulmonary Emphysema and Mediates Matrix Metalloproteinase-1 Induction by Cigarette Smoke
Pyk2 Amplifies Epidermal Growth Factor and c-Src-induced Stat3 Activation
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells
A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
Slit Protein-mediated Inhibition of CXCR4-induced Chemotactic and Chemoinvasive Signaling Pathways in Breast Cancer Cells
Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt
Leptin Stimulates Tissue Inhibitor of Metalloproteinase-1 in Human Hepatic Stellate Cells
G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.
Basic Fibroblast Growth Factor Stimulates Activation of Rac1 through a p85 βPIX Phosphorylation-dependent Pathway
Increases in estrogen receptor‐α concentration in breast cancer cells promote serine 118/104/106‐independent AF‐1 transactivation and growth in the absence of estrogen
Role of Bim in the survival pathway induced by Raf in epithelial cells
LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.
Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
RGD-containing Peptides Activate S6K1 through β3 Integrin in Adult Cardiac Muscle Cells
Epidermal Growth Factor Receptor Is a Common Mediator of Quinone-induced Signaling Leading to Phosphorylation of Connexin-43
Dual mechanisms of green tea extract‐induced cell survival in human epidermal keratinocytes
Sequence-specific Peptide Aptamers, Interacting with the Intracellular Domain of the Epidermal Growth Factor Receptor, Interfere with Stat3 Activation and Inhibit the Growth of Tumor Cells
Regulation of Raf through Phosphorylation and N Terminus-C Terminus Interaction
Morphine Induces Desensitization of Insulin Receptor Signaling
Enhanced Estrogen Receptor (ER) α, ERBB2, and MAPK Signal Transduction Pathways Operate during the Adaptation of MCF-7 Cells to Long Term Estrogen Deprivation
The Bcr Kinase Downregulates Ras Signaling by Phosphorylating AF-6 and Binding to Its PDZ Domain
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis
TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.
Reduced Activation of Phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor Substrate-1 in Primary Culture of Skeletal Muscle Cells From Patients With Type 2 Diabetes
Mechanism of Mitosis-specific Activation of MEK1
Amino Acids Interfere with the ERK1/2-dependent Control of Macroautophagy by Controlling the Activation of Raf-1 in Human Colon Cancer HT-29 Cells
Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa).
Mitogen-Activated Protein Kinase Regulates Nuclear Association of Human Progesterone Receptors
High Density Lipoprotein-induced Endothelial Nitric-oxide Synthase Activation Is Mediated by Akt and MAP Kinases
Histamine activates tyrosine hydroxylase in bovine adrenal chromaffin cells through a pathway that involves ERK1/2 but not p38 or JNK
Akt-Dependent Phosphorylation of Serine 1179 and Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase 1/2 Cooperatively Mediate Activation of the Endothelial Nitric-Oxide Synthase by Hydrogen Peroxide
Insulin-like Growth Factor-binding Protein-3 Potentiates Epidermal Growth Factor Action in MCF-10A Mammary Epithelial Cells
Salicylic Acid Reverses Phorbol 12-Myristate-13-Acetate (PMA)- and Tumor Necrosis Factor α (TNFα)-induced Insulin Receptor Substrate 1 (IRS1) Serine 307 Phosphorylation and Insulin Resistance in Human Embryonic Kidney 293 (HEK293) Cells
Absence of Adhesion Triggers Differential FAK and SAPKp38 Signals in SW620 Human Colon Cancer Cells that may Inhibit Adhesiveness and Lead to Cell Death
Statin inhibits interferon-γ-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells
BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.
Phosphorylation of 338SSYY341 Regulates Specific Interaction between Raf-1 and MEK1
The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation
Gα and Gβγ Require Distinct Src-dependent Pathways to Activate Rap1 and Ras
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
β2-Adrenergic Receptor Lacking the Cyclic AMP-Dependent Protein Kinase Consensus Sites Fully Activates Extracellular Signal-Regulated Kinase 1/2 in Human Embryonic Kidney 293 Cells: Lack of Evidence for Gs/GiSwitching.
1,25-Dihydroxyvitamin D Down-regulates Cell Membrane Growth- and Nuclear Growth-promoting Signals by the Epidermal Growth Factor Receptor
TITLE UNAVAILABLE
IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.
The Neuron-Specific Rai (ShcC) Adaptor Protein Inhibits Apoptosis by Coupling Ret to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway
Distinct Cell Cycle Timing Requirements for Extracellular Signal-Regulated Kinase and Phosphoinositide 3-Kinase Signaling Pathways in Somatic Cell Mitosis
Distinct Nongenomic Signal Transduction Pathways Controlled by 17β-Estradiol Regulate DNA Synthesis and Cyclin D1 Gene Transcription in HepG2 Cells
Akt Activation Induced by Lysophosphatidic Acid and Sphingosine-1-phosphate Requires Both Mitogen-Activated Protein Kinase Kinase and p38 Mitogen-Activated Protein Kinase and Is Cell-Line Specific
Regulation of Raf-Akt Cross-talk
Endostatin Blocks Vascular Endothelial Growth Factor-mediated Signaling via Direct Interaction with KDR/Flk-1
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action.
A Therapeutic CD4 Monoclonal Antibody Inhibits TCR-ζ Chain Phosphorylation, ζ-Associated Protein of 70-kDa Tyr319 Phosphorylation, and TCR Internalization in Primary Human T Cells
Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.
14-3-3 Antagonizes Ras-Mediated Raf-1 Recruitment to the Plasma Membrane To Maintain Signaling Fidelity
c-Raf/MEK/ERK Pathway Controls Protein Kinase C-mediated p70S6K Activation in Adult Cardiac Muscle Cells
Regulation of Erythropoietin-induced STAT Serine Phosphorylation by Distinct Mitogen-activated Protein Kinases
Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.
CTLA-4 Suppresses Proximal TCR Signaling in Resting Human CD4+ T Cells by Inhibiting ZAP-70 Tyr319 Phosphorylation: A Potential Role for Tyrosine Phosphatases
Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras-Induced Premature Senescence
Exposure of Cryptic Domains in the α1-chain of Laminin-1 by Elastase Stimulates Macrophages Urokinase and Matrix Metalloproteinase-9 Expression
Stimulation of protein kinase B and p70 S6 kinase by the histamine H1 receptor in DDT1 MF-2 smooth muscle cells
Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1-dependent Genes in Endothelial Cells
Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma
Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism
Fibroblast Growth Factor-1 Induced Promatrilysin Expression Through the Activation of Extracellular-regulated Kinases and STAT3
A Mitogen-activated Protein Kinase-dependent Signaling Pathway in the Activation of Platelet Integrin αIIbβ3
The Inhibitory γ Subunit of the Type 6 Retinal Cyclic Guanosine Monophosphate Phosphodiesterase Is a Novel Intermediate Regulating p42/p44 Mitogen-activated Protein Kinase Signaling in Human Embryonic Kidney 293 Cells
Roles of Phosphatidylinositol 3-Kinase in Interferon-γ-dependent Phosphorylation of STAT1 on Serine 727 and Activation of Gene Expression
Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity
Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking
Phosphorylation of MafA Is Essential for Its Transcriptional and Biological Properties
Phosphorylation of Nuclear Phospholipase C β1 by Extracellular Signal-Regulated Kinase Mediates the Mitogenic Action of Insulin-Like Growth Factor I
Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase
Inhibition of Cell Migration by 24-kDa Fibroblast Growth Factor-2 Is Dependent upon the Estrogen Receptor
Stimulation of Mitogen-Activated Protein Kinase by Gonadotropin-Releasing Hormone in Human Granulosa-Luteal Cells**This work was supported grants from the Medical Research Council of Canada.
Mitogenic and Antiapoptotic Actions of Hepatocyte Growth Factor Through ERK, STAT3, and Akt in Endothelial Cells
Regulation of Cbl Molecular Interactions by the Co-receptor Molecule CD43 in Human T Cells
Non-redundant Signal Transduction of Interleukin-6-type Cytokines
Salicylate-induced Growth Arrest Is Associated with Inhibition of p70s6k and Down-regulation of c-Myc, Cyclin D1, Cyclin A, and Proliferating Cell Nuclear Antigen
8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein
Insulin Activation of Mitogen-activated Protein Kinases Erk1,2 Is Amplified via β-adrenergic Receptor Expression and Requires the Integrity of the Tyr350 of the Receptor
Integrin Activation and Focal Complex Formation in Cardiac Hypertrophy
Chimeric VEGFRs are activated by a small-molecule dimerizer and mediate downstream signalling cascades in endothelial cells
Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways
Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.
The docking molecule Gab2 is induced by lymphocyte activation and is involved in signaling by Interleukin-2 and Interleukin-15 but not other common gamma chain-using cytokines
Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation
Oncostatin M Stimulates the Growth of Dermal Fibroblasts Via a Mitogen-Activated Protein Kinase-Dependent Pathway
Protein-tyrosine Kinase Pyk2 Is Involved in Interleukin-2 Production by Jurkat T Cells via Its Tyrosine 402
Activation of Downstream Signals by the Long Form of the Leptin Receptor
Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473
The Linker Phosphorylation Site Tyr292 Mediates the Negative Regulatory Effect of Cbl on ZAP-70 in T Cells
A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts
Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle
Coupling of M2 muscarinic receptors to ERK MAP kinases and caldesmon phosphorylation in colonic smooth muscle
Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1
A Novel Apoptotic Pathway Induced by Nerve Growth Factor-mediated TrkA Activation in Medulloblastoma
The Inhibitory Function of CTLA-4 Does Not Require Its Tyrosine Phosphorylation
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
Rapid STAT Phosphorylation via the B Cell Receptor
Rapid signalling by androgen receptor in prostate cancer cells
Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation
Fibroblast Growth Factor Receptor-1-mediated Endothelial Cell Proliferation Is Dependent on the Src Homology (SH) 2/SH3 Domain-containing Adaptor Protein Crk
Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).
The MEK1 Proline-rich Insert Is Required for Efficient Activation of the Mitogen-activated Protein Kinases ERK1 and ERK2 in Mammalian Cells
Expression of Q227L-G s in MCF-7 human breast cancer cells inhibits tumorigenesis
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
A quantitative atlas of mitotic phosphorylation.
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| 187 | Y | Phosphorylation | Phosphotyrosine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Epidermal growth factor receptor signaling suppresses αvβ6 integrin and promotes periodontal inflammation and bone loss
The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells
The Prolyl Isomerase Pin1 Controls Lipopolysaccharide-Induced Priming of NADPH Oxidase in Human Neutrophils
Biased antagonism of CXCR4 avoids antagonist tolerance
Mechanisms for DNA‑damaging agent‑induced inactivation of ErbB2 and ErbB3 via the ERK and p38 signaling pathways
Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells
Phosphorylation of the C-Raf N Region Promotes Raf Dimerization
Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells
Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer
Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors
Interdependence of JAK-STAT and MAPK signaling pathways during EGF-mediated HTR-8/SVneo cell invasion
Comparison of Acalabrutinib, A Selective Bruton Tyrosine Kinase Inhibitor, with Ibrutinib in Chronic Lymphocytic Leukemia Cells
Gas6/AXL Signaling Regulates Self-Renewal of Chronic Myelogenous Leukemia Stem Cells by Stabilizing β-Catenin
CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency
Idelalisib Impacts Cell Growth through Inhibiting Translation-Regulatory Mechanisms in Mantle Cell Lymphoma
Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway
Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography
Evidence for Pro-angiogenic Functions of VEGF-Ax
Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways
Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling
Loss of MLCK leads to disruption of cell–cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling
A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation
KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway
Laminin-111 peptide C16 regulates invadopodia activity of malignant cells through β1 integrin, Src and ERK 1/2
Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
Proteogenomics connects somatic mutations to signalling in breast cancer
Multiomic Analysis of the UV-Induced DNA Damage Response
Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling
PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies
Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities
Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression
Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494
Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells
Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2
Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells
mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells
Role of Erk1/2 Signaling in the Regulation of Neutrophil Versus Monocyte Development in Response to G-CSF and M-CSF
Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells
EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function
Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient–Derived Xenograft Models
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Leupaxin stimulates adhesion and migration of prostate cancer cells through modulation of the phosphorylation status of the actin-binding protein caldesmon
ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion
A Lactate-Induced Response to Hypoxia
Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors
Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts
Phospho-STIM1 is a downstream effector that mediates the signaling triggered by IGF-1 in HEK293 cells
Structural assembly of the signaling competent ERK2–RSK1 heterodimeric protein kinase complex
PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester
MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1
Neurotrophin Signaling via TrkB and TrkC Receptors Promotes the Growth of Brain Tumor-initiating Cells
Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth
Functional Consequences of 17q21.31/WNT3-WNT9B Amplification in hPSCs with Respect to Neural Differentiation
Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction.
RasGRP3 regulates the migration of glioma cells via interaction with Arp3
Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance.
The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation
Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis
14-3-3 Proteins Buffer Intracellular Calcium Sensing Receptors to Constrain Signaling
Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells
Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells
Dimethylfumarate protects against TNF-α-induced secretion of inflammatory cytokines in human endothelial cells
Short-term high glucose exposure impairs insulin signaling in endothelial cells
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics
Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition
Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation
The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway
Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia
Angiogenin promotes tumoral growth and angiogenesis by regulating matrix metallopeptidase-2 expression via the ERK1/2 pathway
Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance
Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via the Lyn-PI3K/AKT pathway
Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion
Quantitative Analysis of Signaling Networks across Differentially Embedded Tumors Highlights Interpatient Heterogeneity in Human Glioblastoma
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
A secreted tyrosine kinase acts in the extracellular environment.
Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma
Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non–Small Cell Lung Cancer
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells
Adducin Is Required for Desmosomal Cohesion in Keratinocytes
Global Phosphoproteomic Profiling Reveals Distinct Signatures in B-Cell Non-Hodgkin Lymphomas
Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis
EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368
G-Protein–Coupled Receptor-2–Interacting Protein-1 Is Required for Endothelial Cell Directional Migration and Tumor Angiogenesis via Cortactin-Dependent Lamellipodia Formation
A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
Vascular Endothelial Tight Junctions and Barrier Function Are Disrupted by 15(S)-Hydroxyeicosatetraenoic Acid Partly via Protein Kinase Cϵ-mediated Zona Occludens-1 Phosphorylation at Threonine 770/772
Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)–ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration
Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
The known interactome of PTPIP51 in HaCaT cells—Inhibition of kinases and receptors
Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma
Quantification of Pancreatic Cancer Proteome and Phosphorylome: Indicates Molecular Events Likely Contributing to Cancer and Activity of Drug Targets
Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells
YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma
Phosphocaveolin-1 Enforces Tumor Growth and Chemoresistance in Rhabdomyosarcoma
Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins
Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y1086, c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity
Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1
pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner
p120 catenin is a key effector of a Ras-PKCɛ oncogenic signaling axis
Metformin Represses Drug-Induced Expression of CYP2B6 by Modulating the Constitutive Androstane Receptor Signaling
Estrogen protects SGC7901 cells from endoplasmic reticulum stress-induced apoptosis by the Akt pathway
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1
Design optimization and characterization of Her2/neu-targeted immunotoxins: comparative in vitro and in vivo efficacy studies
p38-Mediated phosphorylation of Eps15 endocytic adaptor protein
Casein Kinase 1ε Promotes Cell Proliferation by Regulating mRNA Translation
Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration
Inhibition of STIM1 phosphorylation underlies resveratrol-induced inhibition of store-operated calcium entry
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors
Tyrosine Phosphorylation of CD13 Regulates Inflammatory Cell–Cell Adhesion and Monocyte Trafficking
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)
Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells
Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1
Integrated proteomic analysis of post-translational modifications by serial enrichment
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines
Recruitment of Nox4 to a Plasma Membrane Scaffold Is Required for Localized Reactive Oxygen Species Generation and Sustained Src Activation in Response to Insulin-like Growth Factor-I
Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase Cϵ Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation
Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.
Phosphotyrosine Profiling of NSCLC Cells in Response to EGF and HGF Reveals Network Specific Mediators of Invasion
Mitogen-activated protein kinase modulates ethanol inhibition of cell adhesion mediated by the L1 neural cell adhesion molecule
A novelSOS1mutation in Costello/CFC syndrome affects signaling in both RAS and PI3K pathways
p38α phosphorylates serine 258 within the cytoplasmic domain of tissue factor and prevents its incorporation into cell-derived microparticles
cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.
Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway
CDK inhibitor p57Kip2 is downregulated by Akt during HER2-mediated tumorigenicity
ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser777 Inhibits Signaling
Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Global Phosphotyrosine Proteomics Identifies PKCδ as a Marker of Responsiveness to Src Inhibition in Colorectal Cancer
Molecular Mechanisms and Modulation of Key Pathways Underlying the Synergistic Interaction of Sorafenib with Erlotinib in Non-Small-Cell-Lung Cancer (NSCLC) Cells
ERK Positive Feedback Regulates a Widespread Network of Tyrosine Phosphorylation Sites across Canonical T Cell Signaling and Actin Cytoskeletal Proteins in Jurkat T Cells
Quantitative Phosphoproteomic Analysis Identifies Activation of the RET and IGF-1R/IR Signaling Pathways in Neuroblastoma
Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors
Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop
Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin
Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587
Novel involvement of leukotriene B4 receptor 2 through ERK activation by PP2A down-regulation in leukotriene B4-induced keratin phosphorylation and reorganization of pancreatic cancer cells
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Molecular Characterization of EGFR and EGFRvIII Signaling Networks in Human Glioblastoma Tumor Xenografts
RSK2Ser227 at N-Terminal Kinase Domain Is a Potential Therapeutic Target for Multiple Myeloma
Extracellular Signal-regulated Kinase 2 (ERK2) Mediates Phosphorylation and Inactivation of Nuclear Interaction Partner of Anaplastic Lymphoma Kinase (NIPA) at G2/M*
The TLR7/8 Agonist CL097 PrimesN-Formyl-Methionyl-Leucyl-Phenylalanine–Stimulated NADPH Oxidase Activation in Human Neutrophils: Critical Role of p47phox Phosphorylation and the Proline Isomerase Pin1
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Coregulation of Multiple Signaling Mechanisms in pp60v-Src-Induced Closure of Cx43 Gap Junction Channels
Phosphoproteomic Analysis of Leukemia Cells under Basal and Drug-treated Conditions Identifies Markers of Kinase Pathway Activation and Mechanisms of Resistance*
Time-Resolved Quantitative Phosphoproteomics: New Insights into Angiotensin-(1–7) Signaling Networks in Human Endothelial Cells
c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1
Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors
Lyn Kinase Mediates Cell Motility and Tumor Growth in EGFRvIII-Expressing Head and Neck Cancer
PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS
Quantitative Phosphoproteomic Analysis Reveals a Role for Serine and Threonine Kinases in the Cytoskeletal Reorganization in Early T Cell Receptor Activation in Human Primary T Cells
Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Intestinal Cell Kinase (ICK) Promotes Activation of mTOR Complex 1 (mTORC1) through Phosphorylation of Raptor Thr-908*
P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation
Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation
Inhibition of Insulin Signaling in Endothelial Cells by Protein Kinase C-induced Phosphorylation of p85 Subunit of Phosphatidylinositol 3-Kinase (PI3K)*
Protein-tyrosine Kinase 6 Promotes Peripheral Adhesion Complex Formation and Cell Migration by Phosphorylating p130 CRK-associated Substrate*
Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2.
ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells
Importance of Domain Closure for the Autoactivation of ERK2
Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.
A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction
Involvement of Protein Kinase Cδ/Extracellular Signal-regulated Kinase/Poly(ADP-ribose) Polymerase-1 (PARP-1) Signaling Pathway in Histamine-induced Up-regulation of Histamine H1 Receptor Gene Expression in HeLa Cells
Oncogenic role of EAPII in lung cancer development and its activation of the MAPK–ERK pathway
Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation
Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer
HGF-independent potentiation of EGFR action by c-Met
Distinct Phosphorylation Sites on the 2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of -Arrestin
Processive phosphorylation of ERK MAP kinase in mammalian cells
VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation
Toward a comprehensive characterization of the phosphotyrosine proteome
Phosphorylation of Histone H2B Serine 32 Is Linked to Cell Transformation
Aberrant ribosome biogenesis activates c-Myc and ASK1 pathways resulting in p53-dependent G1 arrest
Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells
Phosphorylation of serine 21 modulates the proliferation inhibitory more than the differentiation inducing effects of C/EBPα in K562 cells
Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation
Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor
Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia
Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics
Glabridin Inhibits Migration, Invasion, and Angiogenesis of Human Non–Small Cell Lung Cancer A549 Cells by Inhibiting the FAK/Rho Signaling Pathway
A Novel Kinase Inhibitor, INCB28060, Blocks c-MET–Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3
Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling
Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways
Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma
Cell Cycle Phase Regulates Glucocorticoid Receptor Function
Resveratrol Inhibits Growth of Orthotopic Pancreatic Tumors through Activation of FOXO Transcription Factors
Survey of Activated FLT3 Signaling in Leukemia
A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling
Btk is a positive regulator in the TREM-1/DAP12 signaling pathway.
Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells
Quantitative Phospho-Proteomic Profiling of Hepatocyte Growth Factor (HGF)-MET Signaling in Colorectal Cancer
Combination of PI3K/mTOR Inhibitors: Antitumor Activity and Molecular Correlates
Bim Protein Degradation Contributes to Cisplatin Resistance
cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway
PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis.
Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition
B7-H2 Is a Costimulatory Ligand for CD28 in Human
Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer
Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
Optimization of immunoaffinity enrichment and detection: toward a comprehensive characterization of the phosphotyrosine proteome of K562 cells by liquid chromatography-mass spectrometry
Phosphomimetic Substitution of Heterogeneous Nuclear Ribonucleoprotein A1 at Serine 199 Abolishes AKT-dependent Internal Ribosome Entry Site-transacting Factor (ITAF) Function via Effects on Strand Annealing and Results in Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitor Sensitivity
Receptor-type Protein Tyrosine Phosphatase β (RPTP-β) Directly Dephosphorylates and Regulates Hepatocyte Growth Factor Receptor (HGFR/Met) Function
ERK and PDE4 cooperate to induce RAF isoform switching in melanoma
Transient PI3K Inhibition Induces Apoptosis and Overcomes HGF-Mediated Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer
A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions
Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling
Tyrosine kinase-independent activation of extracellular-regulated kinase (ERK) 1/2 by the insulin-like growth factor-1 receptor
Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells: implication of EPCR, noncanonical NF-κB, and ERK1/2 MAP kinases
ERK1 and ERK2 are involved in recruitment and maturation of human mesenchymal stem cells induced to adipogenic differentiation
SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex.
Analysis of Phosphotyrosine Signaling in Glioblastoma Identifies STAT5 as a Novel Downstream Target of ΔEGFR
Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition
High dose human insulin and insulin glargine promote T24 bladder cancer cell proliferation via PI3K-independent activation of Akt
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells
SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein
Survey of Tyrosine Kinase Signaling Reveals ROS Kinase Fusions in Human Cholangiocarcinoma
Tyrosine Phosphorylation Profiling in FGF-2 Stimulated Human Embryonic Stem Cells
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Phasic Phosphorylation of Caldesmon and ERK 1/2 during Contractions in Human Myometrium
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment
HER1 Signaling Mediates Extravillous Trophoblast Differentiation in Humans1
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.
Alternative ERK5 regulation by phosphorylation during the cell cycle
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor
An Informatics-assisted Label-free Quantitation Strategy that Depicts Phosphoproteomic Profiles in Lung Cancer Cell Invasion
IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines
Profiling Y561-Dependent and -Independent Substrates of CSF-1R in Epithelial Cells
p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients
In-depth Analyses of Kinase-dependent Tyrosine Phosphoproteomes Based on Metal Ion-functionalized Soluble Nanopolymers
A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage
Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling
Quantitative Phosphoproteomics of Proteasome Inhibition in Multiple Myeloma Cells
Cross-talk between Serine/Threonine Protein Phosphatase 2A and Protein Tyrosine Phosphatase 1B Regulates Src Activation and Adhesion of Integrin αIIbβ3 to Fibrinogen
Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry
Paxillin Regulates Androgen- and Epidermal Growth Factor-induced MAPK Signaling and Cell Proliferation in Prostate Cancer Cells*
Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
Global phosphorylation analysis of -arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)
Regulation of Prostate Cancer Cell Survival by Protein Kinase C∈ Involves Bad Phosphorylation and Modulation of the TNFα/JNK Pathway
Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance
A stress survival response in retinal cells mediated through inhibition of the serine / threonine phosphatase PP2A
The Combination of Multiple Receptor Tyrosine Kinase Inhibitor and Mammalian Target of Rapamycin Inhibitor Overcomes Erlotinib Resistance in Lung Cancer Cell Lines through c-Met Inhibition
Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
SIRPα1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration
Suppressor of Cytokine Signaling 2 Regulates IL-15–Primed Human NK Cell Function via Control of Phosphorylated Pyk2
Studies of Phosphoproteomic Changes Induced by Nucleophosmin-Anaplastic Lymphoma Kinase (ALK) Highlight Deregulation of Tumor Necrosis Factor (TNF)/Fas/TNF-related Apoptosis-induced Ligand Signaling Pathway in ALK-positive Anaplastic Large Cell Lymphoma
Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
Comprehensive Mapping of the Human Kinome to Epidermal Growth Factor Receptor Signaling*
Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta.
Priming of Signal Transducer and Activator of Transcription Proteins for Cytokine-Triggered Polyubiquitylation and Degradation by the A2A Adenosine Receptor
Quantitative Site-specific Phosphorylation Dynamics of Human Protein Kinases during Mitotic Progression
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
Tau Potentiates Nerve Growth Factor-induced Mitogen-activated Protein Kinase Signaling and Neurite Initiation without a Requirement for Microtubule Binding*
Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis
Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
An Integrated Phosphoproteomics Work Flow Reveals Extensive Network Regulation in Early Lysophosphatidic Acid Signaling
Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis
Proteinase‐activated receptors induce interleukin‐8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation
Protein kinase Cɛ mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2)
Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.
IGFBP7 Is Not Required for B-RAF-Induced Melanocyte Senescence
Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells
Signal Transducers and Activators of Transcription-3 Binding to the Fibroblast Growth Factor Receptor Is Activated by Receptor Amplification
Extracellular Signal-Regulated Kinase 8–Mediated c-Jun Phosphorylation Increases Tumorigenesis of Human Colon Cancer
Sp1/NFκB/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia
Role of Epidermal Growth Factor Receptor Degradation in Cisplatin-Induced Cytotoxicity in Head and Neck Cancer
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
Identification of activated Tnk1 kinase in Hodgkin's lymphoma
Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor
Copine-III interacts with ErbB2 and promotes tumor cell migration.
mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm
Prostaglandin F2α Represses IGF-I-Stimulated IRS1/Phosphatidylinositol-3-Kinase/AKT Signaling in the Corpus Luteum: Role of ERK and P70 Ribosomal S6 Kinase
Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death
Activation of the Integrin Effector Kinase Focal Adhesion Kinase in Cancer Cells Is Regulated by Crosstalk between Protein Kinase C and the PDZ Adapter Protein mda-9/Syntenin
MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
IAP Regulation of Metastasis
A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells
Sunitinib Induces Apoptosis and Growth Arrest of Medulloblastoma Tumor Cells by Inhibiting STAT3 and AKT Signaling Pathways
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Modulation of Akt and ERK1/2 Pathways by Resveratrol in Chronic Myelogenous Leukemia (CML) Cells Results in the Downregulation of Hsp70
Phospholipase D1 Mediates AMP-Activated Protein Kinase Signaling for Glucose Uptake
Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids
A Loss-of-Function Screen Reveals Ras- and Raf-Independent MEK-ERK Signaling During Chlamydia trachomatis Infection
Rapamycin Inhibits IGF-1 Stimulated Cell Motility through PP2A Pathway
Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin21-157
Distinct Changes in cAMP and Extracellular Signal-Regulated Protein Kinase Signalling in L-DOPA-Induced Dyskinesia
Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells
Basic Design of MRM Assays for Peptide Quantification
Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes
Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death
Serine phosphorylation of NPM-ALK, which is dependent on the auto-activation of the kinase activation loop, contributes to its oncogenic potential
Inhibition of Grb2 expression demonstrates an important role in BCR–ABL-mediated MAPK activation and transformation of primary human hematopoietic cells
Annexin‐1 signals mitogen‐stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2
IL-6 Trans-Signaling in Formation and Progression of Malignant Ascites in Ovarian Cancer
C/EBP expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway
Prolactin and estradiol utilize distinct mechanisms to increase serine-118 phosphorylation and decrease levels of estrogen receptor α in T47D breast cancer cells
Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway
c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells
mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation
Overexpression of Phospho-eIF4E Is Associated with Survival through AKT Pathway in Non-Small Cell Lung Cancer
Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor α and its phosphorylation at serine 305
Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions
Cannabinoid Receptor Type 1- and 2-mediated Increase in Cyclic AMP Inhibits T Cell Receptor-triggered Signaling
Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin-Expressing Cells
Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics*
Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis
EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin
Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition
In vivoPhosphoproteome of Human Skeletal Muscle Revealed by Phosphopeptide Enrichment and HPLC−ESI−MS/MS
An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.
A New Approach for Quantitative Phosphoproteomic Dissection of Signaling Pathways Applied to T Cell Receptor Activation*
c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential
Dependence of EGF-Induced Increases in Corneal Epithelial Proliferation and Migration on GSK-3 Inactivation
Novel phosphotyrosine targets of FGFR2IIIb signaling.
The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R
Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration
Raptor Binds the SAIN (Shc and IRS-1 NPXY Binding) Domain of Insulin Receptor Substrate-1 (IRS-1) and Regulates the Phosphorylation of IRS-1 at Ser-636/639 by mTOR
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.
Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS
An Extensive Survey of Tyrosine Phosphorylation Revealing New Sites in Human Mammary Epithelial Cells
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.
Large-scale proteomics analysis of the human kinome.
Mechanism of Activation and Functional Role of Protein Kinase Cη in Human Platelets
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration.
Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets
Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment
Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling.
MEK1 Binds Directly to βArrestin1, Influencing Both Its Phosphorylation by ERK and the Timing of Its Isoprenaline-stimulated Internalization
Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.
EphA2 Engages Git1 to Suppress Arf6 Activity Modulating Epithelial Cell–Cell Contacts
CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells
Activation of the unliganded estrogen receptor by prolactin in breast cancer cells
S6 Kinase 1 Regulates Estrogen Receptor α in Control of Breast Cancer Cell Proliferation
Tectoridin, a poor ligand of estrogen receptor α, exerts its estrogenic effects via an ERK-dependent pathway
Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor
Negative and Positive Regulation of MAPK Phosphatase 3 Controls Platelet-derived Growth Factor-induced Erk Activation
Mechanisms of Sleep-Dependent Consolidation of Cortical Plasticity
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.
The Lysyl Oxidase Pro-peptide Attenuates Fibronectin-mediated Activation of Focal Adhesion Kinase and p130Cas in Breast Cancer Cells
Silibinin Suppresses Growth of Human Prostate Carcinoma PC-3 Orthotopic Xenograft via Activation of Extracellular Signal-Regulated Kinase 1/2 and Inhibition of Signal Transducers and Activators of Transcription Signaling
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway.
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy.
ERK1/2 Mediate Wounding- and G-protein-Coupled Receptor Ligands-Induced EGFR Activation via Regulating ADAM17 and HB-EGF Shedding
T Cell Adhesion Primes Antigen Receptor-Induced Calcium Responses through a Transient Rise in Adenosine 3′,5′-Cyclic Monophosphate
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation
A Concerted Kinase Interplay Identifies PPARγ as a Molecular Target of Ghrelin Signaling in Macrophages
Phosphatase-Dependent Regulation of Epithelial Mitogen-Activated Protein Kinase Responses to Toxin-Induced Membrane Pores
Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells
Short-Term Overeating Induces Insulin Resistance in Fat Cells in Lean Human Subjects
Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha
Epidermal growth factor receptor mutations in non-small cell lung cancer influence downstream Akt, MAPK and Stat3 signaling
Cyclin-Dependent Kinase-3–Mediated c-Jun Phosphorylation at Ser63 and Ser73 Enhances Cell Transformation
Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells
A new mechanism for the regulation of Gab1 recruitment to the plasma membrane
Stereochemistry of an Agonist Determines Coupling Preference of β2-Adrenoceptor to Different G Proteins in Cardiomyocytes
Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene
Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation
Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase.
Enzastaurin, an inhibitor of PKCβ, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells
Follistatin-like 1, a Secreted Muscle Protein, Promotes Endothelial Cell Function and Revascularization in Ischemic Tissue through a Nitric-oxide Synthase-dependent Mechanism
Characterization of Ser338 Phosphorylation for Raf-1 Activation
Cytokine-Induced Signaling Networks Prioritize Dynamic Range over Signal Strength
MLK3 Limits Activated Gαq Signaling to Rho by Binding to p63RhoGEF
WNK2 modulates MEK1 activity through the Rho GTPase pathway.
Phosphorylation of p27Kip1 Regulates Assembly and Activation of Cyclin D1-Cdk4
Identification and characterization of a general nuclear translocation signal in signaling proteins.
Immobilized Metal Affinity Chromatography Revisited: pH/Acid Control toward High Selectivity in Phosphoproteomics
Essential Role of ERK Dimers in the Activation of Cytoplasmic but Not Nuclear Substrates by ERK-Scaffold Complexes
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
A quantitative atlas of mitotic phosphorylation.
TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment
siRNA-Mediated Reduction of Inhibitor of Nuclear Factor- B Kinase Prevents Tumor Necrosis Factor- -Induced Insulin Resistance in Human Skeletal Muscle
Phosphorylated Heat Shock Protein 27 Represses Growth of Hepatocellular Carcinoma via Inhibition of Extracellular Signal-regulated Kinase
γ-Irradiation–Induced DNA Damage Checkpoint Activation Involves Feedback Regulation between Extracellular Signal-Regulated Kinase 1/2 and BRCA1
NF-κB-dependent Transcriptional Activation in Lung Carcinoma Cells by Farnesol Involves p65/RelA(Ser276) Phosphorylation via the MEK-MSK1 Signaling Pathway
Inhibition of STAT3Tyr705 Phosphorylation by Smad4 Suppresses Transforming Growth Factor β–Mediated Invasion and Metastasis in Pancreatic Cancer Cells
Mutant B-RAF mediates resistance to anoikis via Bad and Bim
Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2.
Akt3 and Mutant V600EB-Raf Cooperate to Promote Early Melanoma Development
Motif-Specific Sampling of Phosphoproteomes
A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Interaction between ERK and GSK3β Mediates Basic Fibroblast Growth Factor-induced Apoptosis in SK-N-MC Neuroblastoma Cells
The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK
Transcriptional Activity of the ΔNp63 Promoter Is Regulated by STAT3
Enzastaurin, a Protein Kinase Cβ Inhibitor, Suppresses Signaling through the Ribosomal S6 Kinase and Bad Pathways and Induces Apoptosis in Human Gastric Cancer Cells
Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
mTORC1 Signaling Can Regulate Growth Factor Activation of p44/42 Mitogen-activated Protein Kinases through Protein Phosphatase 2A
PINCH-1 Regulates the ERK-Bim Pathway and Contributes to Apoptosis Resistance in Cancer Cells
Paxillin Phosphorylation Controls Invadopodia/Podosomes Spatiotemporal Organization
Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7.
Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt
A Nurr1 point mutant, implicated in Parkinson’s disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription
AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation
Signaling networks assembled by oncogenic EGFR and c-Met
Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating p27Kip1
Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
Altered PI3-Kinase/Akt Signalling in Skeletal Muscle of Young Men with Low Birth Weight
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells
Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage.
Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
NF-κB Signaling, Elastase Localization, and Phagocytosis Differ in HIV-1 Permissive and Nonpermissive U937 Clones
The SH3 Domain of Lck Modulates T-Cell Receptor-Dependent Activation of Extracellular Signal-Regulated Kinase through Activation of Raf-1
Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
Critical Role of the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase-3β Signaling Pathway in Recovery from Anthrax Lethal Toxin-induced Cell Cycle Arrest and MEK Cleavage in Macrophages
TNFR1 and TNFR2 Signaling Interplay in Cardiac Myocytes
Targeting of FAK Ser910 by ERK5 and PP1δ in non-stimulated and phorbol ester-stimulated cells
Epinephrine Regulation of the Endothelial Nitric-oxide Synthase
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis
Sp3-Mediated VEGF regulation is dependent on phosphorylation by extra-cellular signals regulated kinases (Erk)
SHP-2 is required for the maintenance of cardiac progenitors
Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress.
A Functional Serine 118 Phosphorylation Site in Estrogen Receptor-α Is Required for Down-Regulation of Gene Expression by 17β-Estradiol and 4-Hydroxytamoxifen
EF24 Induces G2/M Arrest and Apoptosis in Cisplatin-resistant Human Ovarian Cancer Cells by Increasing PTEN Expression
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells
Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.
Ribosomal S6 Kinase 2 Is a Key Regulator in Tumor Promoter–Induced Cell Transformation
Regulation of α1-Adrenoceptor-Mediated Contractions of the Uterine Artery by Protein Kinase C: Role of the Thick- and Thin-Filament Regulatory Pathways
Characterization of the activity of human MAP kinase-interacting kinase Mnk1b
FGFR3 Activates RSK2 to Mediate Hematopoietic Transformation through Tyrosine Phosphorylation of RSK2 and Activation of the MEK/ERK Pathway
Ouabain stimulates protein kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway
Possible Role of 5′AMP-Activated Protein Kinase in the Metformin-Mediated Arrest of Bovine Oocytes at the Germinal Vesicle Stage During In Vitro Maturation1
Dimethylfumarate Specifically Inhibits the Mitogen and Stress-Activated Kinases 1 and 2 (MSK1/2): Possible Role for its Anti-Psoriatic Effect
Pressure induces loss of gap junction communication and redistribution of connexin 43 in astrocytes
Identification of S664 TSC2 Phosphorylation as a Marker for Extracellular Signal-Regulated Kinase–Mediated mTOR Activation in Tuberous Sclerosis and Human Cancer
Isoobtusilactone A Induces Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species/Apoptosis Signal-Regulating Kinase 1 Signaling Pathway in Human Breast Cancer Cells
Structure-Function Studies of Allosteric Agonism at M2Muscarinic Acetylcholine Receptors
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
Irradiation-induced G2/M checkpoint response requires ERK1/2 activation
Differential phosphorylation of NG2 proteoglycan by ERK and PKCα helps balance cell proliferation and migration
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia
Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity
Aspirin-Triggered Lipoxins Override the Apoptosis-Delaying Action of Serum Amyloid A in Human Neutrophils: A Novel Mechanism for Resolution of Inflammation
Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells
Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2α (Ser51)
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
Transactivation of the Epidermal Growth Factor Receptor by Formylpeptide Receptor Exacerbates the Malignant Behavior of Human Glioblastoma Cells
Ubiquitin-Independent Proteasomal Degradation of Fra-1 Is Antagonized by Erk1/2 Pathway-Mediated Phosphorylation of a Unique C-Terminal Destabilizer
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling.
Histone Deacetylase Inhibitor Trichostatin A Sustains Sodium Pervanadate-induced NF-κB Activation by Delaying IκBα mRNA Resynthesis
EGFR-T790M Is a Rare Lung Cancer Susceptibility Allele with Enhanced Kinase Activity
Profiling signaling polarity in chemotactic cells
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.
Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells
Tissue Kallikrein Reverses Insulin Resistance and Attenuates Nephropathy in Diabetic Rats by Activation of Phosphatidylinositol 3-Kinase/Protein Kinase B and Adenosine 5′-Monophosphate-Activated Protein Kinase Signaling Pathways
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells
Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage.
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks
Bcl10 Controls TCR- and FcγR-Induced Actin Polymerization
CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor
The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms
Direct Binding of PP2A to Sprouty2 and Phosphorylation Changes Are a Prerequisite for ERK Inhibition Downstream of Fibroblast Growth Factor Receptor Stimulation
Mitogen-activated Protein Kinase-dependent Activation of the Na+/H+ Exchanger Is Mediated through Phosphorylation of Amino Acids Ser770 and Ser771
Ras/ERK1/2-mediated STAT3 Ser727 Phosphorylation by Familial Medullary Thyroid Carcinoma-associated RET Mutants Induces Full Activation of STAT3 and Is Required for c-fos Promoter Activation, Cell Mitogenicity, and Transformation
Proteomics Analysis of Protein Kinases by Target Class-selective Prefractionation and Tandem Mass Spectrometry
Effects of Metformin on Bovine Granulosa Cells Steroidogenesis: Possible Involvement of Adenosine 5′ Monophosphate-Activated Protein Kinase (AMPK)1
Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells
Interleukin-6 Impairs the Insulin Signaling Pathway, Promoting Production of Nitric Oxide in Human Umbilical Vein Endothelial Cells
Inhibition of B56-containing Protein Phosphatase 2As by the Early Response Gene IEX-1 Leads to Control of Akt Activity
Withaferin A Strongly Elicits IκB Kinase β Hyperphosphorylation Concomitant with Potent Inhibition of Its Kinase Activity*
Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker
Extracellular Signal-Related Kinase Positively Regulates Ataxia Telangiectasia Mutated, Homologous Recombination Repair, and the DNA Damage Response
Lapatinib Antitumor Activity Is Not Dependent upon Phosphatase and Tensin Homologue Deleted on Chromosome 10 in ErbB2-Overexpressing Breast Cancers
Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB.
Threonine phosphorylation of integrin β3 in calyculin A-treated platelets is selectively sensitive to 5′-iodotubercidin
Vascular Endothelial Growth Factor Receptor 2 Plays a Role in the Activation of Aortic Endothelial Cells by Oxidized Phospholipids
Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth.
Inactivation of Myocardin and p16 during Malignant Transformation Contributes to a Differentiation Defect
A Key Role of Leptin in the Control of Regulatory T Cell Proliferation
MEK-ERK-mediated Phosphorylation of Mdm2 at Ser-166 in Hepatocytes
PRAK is essential for ras-induced senescence and tumor suppression.
Activation of Akt Predicts Poor Outcome in Neuroblastoma
Repetitive Deformation Activates Focal Adhesion Kinase and ERK Mitogenic Signals in Human Caco-2 Intestinal Epithelial Cells through Src and Rac1
Ca2+-Stimulated Adenylyl Cyclases Regulate ERK-Dependent Activation of MSK1 during Fear Conditioning
RET/Papillary Thyroid Carcinoma Oncogenic Signaling through the Rap1 Small GTPase
Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation
Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling
ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells
Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing
The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway.
Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3
Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis
Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress
Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia.
FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells
Chemokine CXCL12 Induces Binding of Ferritin Heavy Chain to the Chemokine Receptor CXCR4, Alters CXCR4 Signaling, and Induces Phosphorylation and Nuclear Translocation of Ferritin Heavy Chain
TLR4-Dependent NF-κB Activation and Mitogen- and Stress-Activated Protein Kinase 1-Triggered Phosphorylation Events Are Central toHelicobacter pyloriPeptidyl Prolylcis-,trans-Isomerase (HP0175)-Mediated Induction of IL-6 Release from Macrophages
A negative feedback signaling network underlies oncogene-induced senescence
A novel cellular survival factor – the B2 subunit of vacuolar H+-ATPase inhibits apoptosis
Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase Cβ
Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer
Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells
An Inherent Role of Integrin-Linked Kinase-Estrogen Receptor α Interaction in Cell Migration
Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise
PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells
S-Glutathiolation of p21ras by Peroxynitrite Mediates Endothelial Insulin Resistance Caused by Oxidized Low-Density Lipoprotein
A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenes
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
Estrogen-Induced Activation of Mammalian Target of Rapamycin Is Mediated via Tuberin and the Small GTPase Ras Homologue Enriched in Brain
Regulation of androgen receptor activity by tyrosine phosphorylation.
CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex
Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells
Epidermal Growth Factor Protects Prostate Cancer Cells from Apoptosis by Inducing BAD Phosphorylation via Redundant Signaling Pathways
The Isoflavone Equol Mediates Rapid Vascular Relaxation
Suppression of NF-κB Activation by Entamoeba histolytica in Intestinal Epithelial Cells Is Mediated by Heat Shock Protein 27
Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux® ) results in paradox phosphorylation of tyrosine 1173 in the receptor
Rheb Inhibits C-Raf Activity and B-Raf/C-Raf Heterodimerization
Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes
Integrin αVβ3 contains a receptor site for resveratrol
Δ9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
Raf Kinase Inhibitory Protein Regulates Aurora B Kinase and the Spindle Checkpoint
CXCR4 Physically Associates with the T Cell Receptor to Signal in T Cells
Role of c-Src in Human MCF7 Breast Cancer Cell Tumorigenesis
Epidermal growth factor and serum activate distinct pathways to inhibit the BH3 only protein BAD in prostate carcinoma LNCaP cells
Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation
Activation of Gab1 in pancreatic acinar cells: Effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules
Muc4–ErbB2 Complex Formation and Signaling in Polarized CACO-2 Epithelial Cells Indicate That Muc4 Acts as an Unorthodox Ligand for ErbB2
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
Heat Shock Protein 25 or Inducible Heat Shock Protein 70 Activates Heat Shock Factor 1
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.
A common phosphotyrosine signature for the Bcr-Abl kinase
The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.
Flavopiridol Targets c-KIT Transcription and Induces Apoptosis in Gastrointestinal Stromal Tumor Cells
Elevated Expression of Mitogen-Activated Protein Kinase Phosphatase 3 in Breast Tumors: A Mechanism of Tamoxifen Resistance
Attenuation of Peroxisome Proliferator-activated Receptor γ (PPARγ) Mediates Gastrin-stimulated Colorectal Cancer Cell Proliferation
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt
Prognostic Significance of Activated AKT Expression in Soft-Tissue Sarcoma
Activation Function-1 Domain of Estrogen Receptor Regulates the Agonistic and Antagonistic Actions of Tamoxifen
Interaction with Grb14 results in site‐specific regulation of tyrosine phosphorylation of the insulin receptor
Dehydroepiandrosterone Mimics Acute Actions of Insulin to Stimulate Production of Both Nitric Oxide and Endothelin 1 via Distinct Phosphatidylinositol 3-Kinase- and Mitogen-Activated Protein Kinase-Dependent Pathways in Vascular Endothelium
Cyclooxygenase-2 Induction and Prostacyclin Release by Protease-activated Receptors in Endothelial Cells Require Cooperation between Mitogen-activated Protein Kinase and NF-κB Pathways
Basic Fibroblast Growth Factor Protects against Rotenone-Induced Dopaminergic Cell Death through Activation of Extracellular Signal-Regulated Kinases 1/2 and Phosphatidylinositol-3 Kinase Pathways
A Specific Mechanomodulatory Role for p38 MAPK in Embryonic Joint Articular Surface Cell MEK-ERK Pathway Regulation
Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.
Simultaneous Inhibition of PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial Dysfunction and Apoptosis in Acute Myelogenous Leukemia
p38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-α induced endothelial apoptosis
Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions
Oncostatin M Receptor-mediated Signal Transduction Is Negatively Regulated by SOCS3 through a Receptor Tyrosine-independent Mechanism
Integrin α2-mediated ERK and Calpain Activation Play a Critical Role in Cell Adhesion and Motility via Focal Adhesion Kinase Signaling
Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle
Quantitative Analysis of Phosphotyrosine Signaling Networks Triggered by CD3 and CD28 Costimulation in Jurkat Cells
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
IRS-1 Serine Phosphorylation and Insulin Resistance in Skeletal Muscle From Pancreas Transplant Recipients
Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells
Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
c-Myc Phosphorylation Is Required for Cellular Response to Oxidative Stress
Rac1 Modulates Sphingosine 1-Phosphate-mediated Activation of Phosphoinositide 3-Kinase/Akt Signaling Pathways in Vascular Endothelial Cells
Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation
The Raf Inhibitor BAY 43-9006 (Sorafenib) Induces Caspase-Independent Apoptosis in Melanoma Cells
Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.
The Inositol Polyphosphate 5-Phosphatase, PIPP, Is a Novel Regulator of Phosphoinositide 3-Kinase-dependent Neurite Elongation
Selective Repression of Low-Density Lipoprotein Receptor Expression by SP600125: Coupling of Histone H3-Ser10 Phosphorylation and Sp1 Occupancy
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
Oncostatin M-induced activation of stress-activated MAP kinases depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases
ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis
Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases
A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury
Genistein-induced neuronal differentiation is associated with activation of extracellular signal-regulated kinases and upregulation of p21 and N-cadherin
Bone Morphogenetic Protein-2–Induced Transformation Involves the Activation of Mammalian Target of Rapamycin
Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways.
A Positive Feedback Loop between Glycogen Synthase Kinase 3β and Protein Phosphatase 1 after Stimulation of NR2B NMDA Receptors in Forebrain Neurons
Features of the Catalytic Domains and C Termini of the MAPK Signal-integrating Kinases Mnk1 and Mnk2 Determine Their Differing Activities and Regulatory Properties
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors.
Phosphotyrosine Binding-Mediated Oligomerization of Downstream of Tyrosine Kinase (Dok)-1 and Dok-2 Is Involved in CD2-Induced Dok Phosphorylation
Tyrosine Phosphorylation of Caveolin 1 by Oxidative Stress Is Reversible and Dependent on the c-src Tyrosine Kinase but Not Mitogen-Activated Protein Kinase Pathways in Placental Artery Endothelial Cells1
Grb2 negatively regulates epidermal growth factor-induced phospholipase C-γ1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-γ1
Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3.
Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1
Suppression of Urokinase Expression and Invasion by a Soybean Kunitz Trypsin Inhibitor Are Mediated through Inhibition of Src-dependent Signaling Pathways
The Platelet-derived Growth Factor Receptor-β Phosphorylates and Activates G Protein-coupled Receptor Kinase-2
Sprouty-2 Overexpression in C2C12 Cells Confers Myogenic Differentiation Properties in the Presence of FGF2
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry
Direct phosphorylation of proliferative and survival pathway proteins by RET
The Role of Protein-tyrosine Phosphatase 1B in Integrin Signaling
PKC-induced ERK1/2 interactions and downstream effectors in ovine cerebral arteries
The Pro33 Isoform of Integrin β3 Enhances Outside-in Signaling in Human Platelets by Regulating the Activation of Serine/Threonine Phosphatases
Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death.
Raf-1 Serine 338 Phosphorylation Plays a Key Role in Adhesion-Dependent Activation of Extracellular Signal-Regulated Kinase by Epidermal Growth Factor
The Noncatalytic Amino Terminus of Mitogen-Activated Protein Kinase Phosphatase 1 Directs Nuclear Targeting and Serum Response Element Transcriptional Regulation
Transforming Growth Factor β (TGF-β)-Smad Target Gene Protein Tyrosine Phosphatase Receptor Type Kappa Is Required for TGF-β Function
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
Identification of a DEF-type Docking Domain for Extracellular Signal-regulated Kinases 1/2 That Directs Phosphorylation and Turnover of the BH3-only Protein BimEL
Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells.
The Role of Growth Factor Receptor Pathways in Human Breast Cancer Cells Adapted to Long-term Estrogen Deprivation
Dok-R Mediates Attenuation of Epidermal Growth Factor-Dependent Mitogen-Activated Protein Kinase and Akt Activation through Processive Recruitment of c-Src and Csk
The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.
Phosphotyrosine Signaling Networks in Epidermal Growth Factor Receptor Overexpressing Squamous Carcinoma Cells
Insulin-Like Growth Factor 1 Inhibits Extracellular Signal-Regulated Kinase to Promote Neuronal Survival via the Phosphatidylinositol 3-Kinase/Protein Kinase A/c-Raf Pathway
Modulation of Survival Signaling Pathways and Persistence of the Genotoxic Stress as a Basis for the Synergistic Interaction between the Atypical Retinoid ST1926 and the Epidermal Growth Factor Receptor Inhibitor ZD1839
Phosphorylation of Carboxyl-terminal Tyrosines Modulates the Specificity of Sprouty-2 Inhibition of Different Signaling Pathways
Angiopoietin-1 Promotes Cardiac and Skeletal Myocyte Survival Through Integrins
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
Inhibition of Integrin-Linked Kinase by a Selective Small Molecule Inhibitor, QLT0254, Inhibits the PI3K/PKB/mTOR, Stat3, and FKHR Pathways and Tumor Growth, and Enhances Gemcitabine-Induced Apoptosis in Human Orthotopic Primary Pancreatic Cancer Xenografts
c-Jun N-Terminal Kinase Contributes to Aberrant Retinoid Signaling in Lung Cancer Cells by Phosphorylating and Inducing Proteasomal Degradation of Retinoic Acid Receptor α
Disruption of the Shc/Grb2 Complex during Abelson Virus Transformation Affects Proliferation, but Not Apoptosis
Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Regulation of chemotaxis by the cytoplasmic domain of tissue factor
Prolactin-Regulated Tyrosine Hydroxylase Activity and Messenger Ribonucleic Acid Expression in Mediobasal Hypothalamic Cultures: The Differential Role of Specific Protein Kinases
Activation of focal adhesion kinase in human lung cancer cells involves multiple and potentially parallel signaling events
Src Family Kinase Inhibitors Block Amphiregulin-Mediated Autocrine ErbB Signaling in Normal Human Keratinocytes
Connective Tissue Growth Factor CCN2 Interacts with and Activates the Tyrosine Kinase Receptor TrkA
17β-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo
Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites
Activation and translocation of PKCδ is necessary for VEGF-induced ERK activation through KDR in HEK293T cells
Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.
Apelin (65‐77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells
Protein microarrays for multiplex analysis of signal transduction pathways
SHP-2-Dependent Mitogen-Activated Protein Kinase Activation Regulates EGFRvIII but not Wild-Type Epidermal Growth Factor Receptor Phosphorylation and Glioblastoma Cell Survival
Autocrine Transforming Growth Factor α Regulates Cell Adhesion by Multiple Signaling via Specific Phosphorylation Sites of p70S6 Kinase in Colon Cancer Cells
Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle
The Role of Rho Kinase and Extracellular Regulated Kinase-Mitogen-Activated Protein Kinase in α2-Adrenoceptor-Mediated Vasoconstriction in the Porcine Palmar Lateral Vein
Regulation of hormone-sensitive lipase activity and Ser563and Ser565phosphorylation in human skeletal muscle during exercise
Proteomic Identification of Bcl2-associated Athanogene 2 as a Novel MAPK-activated Protein Kinase 2 Substrate
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.
T-cell receptor–induced phosphorylation of the ζ chain is efficiently promoted by ZAP-70 but not Syk
Differential Pathways of Angiotensin II-Induced Extracellularly Regulated Kinase 1/2 Phosphorylation in Specific Cell Types: Role of Heparin-Binding Epidermal Growth Factor
Down-regulation of WW Domain-containing Oxidoreductase Induces Tau Phosphorylation in Vitro
Involvement of protein kinase C-alpha and -epsilon in extracellular Ca2+ signalling mediated by the calcium sensing receptor
Thyroid Hormone Causes Mitogen-Activated Protein Kinase-Dependent Phosphorylation of the Nuclear Estrogen Receptor
Extracellular pressure stimulates macrophage phagocytosis by inhibiting a pathway involving FAK and ERK
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
Tyrosine Phosphorylation of Sprouty Proteins Regulates Their Ability to Inhibit Growth Factor Signaling: A Dual Feedback Loop
Extracellular Regulated Kinase/Mitogen Activated Protein Kinase Is Up-regulated in Pulmonary Emphysema and Mediates Matrix Metalloproteinase-1 Induction by Cigarette Smoke
Pyk2 Amplifies Epidermal Growth Factor and c-Src-induced Stat3 Activation
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells
A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
Slit Protein-mediated Inhibition of CXCR4-induced Chemotactic and Chemoinvasive Signaling Pathways in Breast Cancer Cells
Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt
Leptin Stimulates Tissue Inhibitor of Metalloproteinase-1 in Human Hepatic Stellate Cells
G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.
Basic Fibroblast Growth Factor Stimulates Activation of Rac1 through a p85 βPIX Phosphorylation-dependent Pathway
Increases in estrogen receptor‐α concentration in breast cancer cells promote serine 118/104/106‐independent AF‐1 transactivation and growth in the absence of estrogen
Role of Bim in the survival pathway induced by Raf in epithelial cells
LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.
Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
RGD-containing Peptides Activate S6K1 through β3 Integrin in Adult Cardiac Muscle Cells
Epidermal Growth Factor Receptor Is a Common Mediator of Quinone-induced Signaling Leading to Phosphorylation of Connexin-43
Dual mechanisms of green tea extract‐induced cell survival in human epidermal keratinocytes
Sequence-specific Peptide Aptamers, Interacting with the Intracellular Domain of the Epidermal Growth Factor Receptor, Interfere with Stat3 Activation and Inhibit the Growth of Tumor Cells
Regulation of Raf through Phosphorylation and N Terminus-C Terminus Interaction
Morphine Induces Desensitization of Insulin Receptor Signaling
Enhanced Estrogen Receptor (ER) α, ERBB2, and MAPK Signal Transduction Pathways Operate during the Adaptation of MCF-7 Cells to Long Term Estrogen Deprivation
The Bcr Kinase Downregulates Ras Signaling by Phosphorylating AF-6 and Binding to Its PDZ Domain
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis
TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.
Reduced Activation of Phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor Substrate-1 in Primary Culture of Skeletal Muscle Cells From Patients With Type 2 Diabetes
Mechanism of Mitosis-specific Activation of MEK1
Amino Acids Interfere with the ERK1/2-dependent Control of Macroautophagy by Controlling the Activation of Raf-1 in Human Colon Cancer HT-29 Cells
ERK and RhoA Differentially Regulate Pseudopodia Growth and Retraction during Chemotaxis
Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa).
Mitogen-Activated Protein Kinase Regulates Nuclear Association of Human Progesterone Receptors
High Density Lipoprotein-induced Endothelial Nitric-oxide Synthase Activation Is Mediated by Akt and MAP Kinases
Histamine activates tyrosine hydroxylase in bovine adrenal chromaffin cells through a pathway that involves ERK1/2 but not p38 or JNK
Akt-Dependent Phosphorylation of Serine 1179 and Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase 1/2 Cooperatively Mediate Activation of the Endothelial Nitric-Oxide Synthase by Hydrogen Peroxide
Insulin-like Growth Factor-binding Protein-3 Potentiates Epidermal Growth Factor Action in MCF-10A Mammary Epithelial Cells
Salicylic Acid Reverses Phorbol 12-Myristate-13-Acetate (PMA)- and Tumor Necrosis Factor α (TNFα)-induced Insulin Receptor Substrate 1 (IRS1) Serine 307 Phosphorylation and Insulin Resistance in Human Embryonic Kidney 293 (HEK293) Cells
Absence of Adhesion Triggers Differential FAK and SAPKp38 Signals in SW620 Human Colon Cancer Cells that may Inhibit Adhesiveness and Lead to Cell Death
Statin inhibits interferon-γ-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells
BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.
Phosphorylation of 338SSYY341 Regulates Specific Interaction between Raf-1 and MEK1
The roles of phosphotyrosines-294, -404, and -451 in RET/PTC1-induced thyroid tumor formation
Gα and Gβγ Require Distinct Src-dependent Pathways to Activate Rap1 and Ras
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
β2-Adrenergic Receptor Lacking the Cyclic AMP-Dependent Protein Kinase Consensus Sites Fully Activates Extracellular Signal-Regulated Kinase 1/2 in Human Embryonic Kidney 293 Cells: Lack of Evidence for Gs/GiSwitching.
1,25-Dihydroxyvitamin D Down-regulates Cell Membrane Growth- and Nuclear Growth-promoting Signals by the Epidermal Growth Factor Receptor
TITLE UNAVAILABLE
IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.
The Neuron-Specific Rai (ShcC) Adaptor Protein Inhibits Apoptosis by Coupling Ret to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway
Distinct Cell Cycle Timing Requirements for Extracellular Signal-Regulated Kinase and Phosphoinositide 3-Kinase Signaling Pathways in Somatic Cell Mitosis
Distinct Nongenomic Signal Transduction Pathways Controlled by 17β-Estradiol Regulate DNA Synthesis and Cyclin D1 Gene Transcription in HepG2 Cells
Akt Activation Induced by Lysophosphatidic Acid and Sphingosine-1-phosphate Requires Both Mitogen-Activated Protein Kinase Kinase and p38 Mitogen-Activated Protein Kinase and Is Cell-Line Specific
Regulation of Raf-Akt Cross-talk
Endostatin Blocks Vascular Endothelial Growth Factor-mediated Signaling via Direct Interaction with KDR/Flk-1
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action.
A Therapeutic CD4 Monoclonal Antibody Inhibits TCR-ζ Chain Phosphorylation, ζ-Associated Protein of 70-kDa Tyr319 Phosphorylation, and TCR Internalization in Primary Human T Cells
Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.
14-3-3 Antagonizes Ras-Mediated Raf-1 Recruitment to the Plasma Membrane To Maintain Signaling Fidelity
c-Raf/MEK/ERK Pathway Controls Protein Kinase C-mediated p70S6K Activation in Adult Cardiac Muscle Cells
Regulation of Erythropoietin-induced STAT Serine Phosphorylation by Distinct Mitogen-activated Protein Kinases
Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.
CTLA-4 Suppresses Proximal TCR Signaling in Resting Human CD4+ T Cells by Inhibiting ZAP-70 Tyr319 Phosphorylation: A Potential Role for Tyrosine Phosphatases
Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras-Induced Premature Senescence
Exposure of Cryptic Domains in the α1-chain of Laminin-1 by Elastase Stimulates Macrophages Urokinase and Matrix Metalloproteinase-9 Expression
Stimulation of protein kinase B and p70 S6 kinase by the histamine H1 receptor in DDT1 MF-2 smooth muscle cells
Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1-dependent Genes in Endothelial Cells
Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma
Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism
Fibroblast Growth Factor-1 Induced Promatrilysin Expression Through the Activation of Extracellular-regulated Kinases and STAT3
A Mitogen-activated Protein Kinase-dependent Signaling Pathway in the Activation of Platelet Integrin αIIbβ3
The Inhibitory γ Subunit of the Type 6 Retinal Cyclic Guanosine Monophosphate Phosphodiesterase Is a Novel Intermediate Regulating p42/p44 Mitogen-activated Protein Kinase Signaling in Human Embryonic Kidney 293 Cells
Roles of Phosphatidylinositol 3-Kinase in Interferon-γ-dependent Phosphorylation of STAT1 on Serine 727 and Activation of Gene Expression
Multiple phosphorylation sites in RGS16 differentially modulate its GAP activity
Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking
Phosphorylation of MafA Is Essential for Its Transcriptional and Biological Properties
Phosphorylation of Nuclear Phospholipase C β1 by Extracellular Signal-Regulated Kinase Mediates the Mitogenic Action of Insulin-Like Growth Factor I
Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase
Inhibition of Cell Migration by 24-kDa Fibroblast Growth Factor-2 Is Dependent upon the Estrogen Receptor
Stimulation of Mitogen-Activated Protein Kinase by Gonadotropin-Releasing Hormone in Human Granulosa-Luteal Cells**This work was supported grants from the Medical Research Council of Canada.
Mitogenic and Antiapoptotic Actions of Hepatocyte Growth Factor Through ERK, STAT3, and Akt in Endothelial Cells
Regulation of Cbl Molecular Interactions by the Co-receptor Molecule CD43 in Human T Cells
Non-redundant Signal Transduction of Interleukin-6-type Cytokines
Salicylate-induced Growth Arrest Is Associated with Inhibition of p70s6k and Down-regulation of c-Myc, Cyclin D1, Cyclin A, and Proliferating Cell Nuclear Antigen
8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein
Insulin Activation of Mitogen-activated Protein Kinases Erk1,2 Is Amplified via β-adrenergic Receptor Expression and Requires the Integrity of the Tyr350 of the Receptor
Integrin Activation and Focal Complex Formation in Cardiac Hypertrophy
Chimeric VEGFRs are activated by a small-molecule dimerizer and mediate downstream signalling cascades in endothelial cells
Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways
Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.
The docking molecule Gab2 is induced by lymphocyte activation and is involved in signaling by Interleukin-2 and Interleukin-15 but not other common gamma chain-using cytokines
Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation
Oncostatin M Stimulates the Growth of Dermal Fibroblasts Via a Mitogen-Activated Protein Kinase-Dependent Pathway
Protein-tyrosine Kinase Pyk2 Is Involved in Interleukin-2 Production by Jurkat T Cells via Its Tyrosine 402
Activation of Downstream Signals by the Long Form of the Leptin Receptor
Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473
The Linker Phosphorylation Site Tyr292 Mediates the Negative Regulatory Effect of Cbl on ZAP-70 in T Cells
A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts
Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle
Coupling of M2 muscarinic receptors to ERK MAP kinases and caldesmon phosphorylation in colonic smooth muscle
A dominant role for the c-Jun NH2-terminal kinase in oncogenic ras-induced morphologic transformation of human lung carcinoma cells.
Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1
A Novel Apoptotic Pathway Induced by Nerve Growth Factor-mediated TrkA Activation in Medulloblastoma
The Inhibitory Function of CTLA-4 Does Not Require Its Tyrosine Phosphorylation
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
Rapid STAT Phosphorylation via the B Cell Receptor
Rapid signalling by androgen receptor in prostate cancer cells
Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation
Fibroblast Growth Factor Receptor-1-mediated Endothelial Cell Proliferation Is Dependent on the Src Homology (SH) 2/SH3 Domain-containing Adaptor Protein Crk
Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).
The MEK1 Proline-rich Insert Is Required for Efficient Activation of the Mitogen-activated Protein Kinases ERK1 and ERK2 in Mammalian Cells
Expression of Q227L-G s in MCF-7 human breast cancer cells inhibits tumorigenesis
Differential expression and activation of MAP kinases in dedifferentiated MDCK-focus cells
Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.
Manual assertion based on experiment [ECO:0000269]
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.
Structural basis of substrate recognition by hematopoietic tyrosine phosphatase.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
A quantitative atlas of mitotic phosphorylation.
|
| 190 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells
Quantitative Site-specific Phosphorylation Dynamics of Human Protein Kinases during Mitotic Progression
An Integrated Phosphoproteomics Work Flow Reveals Extensive Network Regulation in Early Lysophosphatidic Acid Signaling
CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy.
Motif-Specific Sampling of Phosphoproteomes
Manual assertion based on experiment [ECO:0000269]
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy.
|
| 193 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts
Analysis of Phosphotyrosine Signaling in Glioblastoma Identifies STAT5 as a Novel Downstream Target of ΔEGFR
|
| 203 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Multiomic Analysis of the UV-Induced DNA Damage Response
Integrated proteomic analysis of post-translational modifications by serial enrichment
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles
|
| 203 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 205 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 206 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 246 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation
Identification and characterization of a general nuclear translocation signal in signaling proteins.
Manual assertion based on experiment [ECO:0000269]
Identification and characterization of a general nuclear translocation signal in signaling proteins.
|
| 248 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
Peer reviewed articles curated by PhosphoSitePlus®.
Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation
Identification and characterization of a general nuclear translocation signal in signaling proteins.
Manual assertion based on experiment [ECO:0000269]
Identification and characterization of a general nuclear translocation signal in signaling proteins.
|
| 259 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 263 | Y | Phosphorylation | Phosphotyrosine |
Peer reviewed articles curated by PhosphoSitePlus®.
Studies of Phosphoproteomic Changes Induced by Nucleophosmin-Anaplastic Lymphoma Kinase (ALK) Highlight Deregulation of Tumor Necrosis Factor (TNF)/Fas/TNF-related Apoptosis-induced Ligand Signaling Pathway in ALK-positive Anaplastic Large Cell Lymphoma
|
| 270 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 272 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 284 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Large-scale proteomics analysis of the human kinome.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Large-scale proteomics analysis of the human kinome.
|
| 285 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Site-specific identification and quantitation of endogenous SUMO modifications under native conditions
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 292 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles
|
| 300 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
|
| 320 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
|
| 330 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
|
| 330 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 340 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
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| 344 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
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| 360 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
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