Canonical isoform: P04626-1 [UniProt]
Other possible isoforms:
P04626-2,
P04626-3,
P04626-4,
P04626-5,
P04626-6
HUGO gene symbols:
Protein name: Receptor tyrosine-protein kinase erbB-2
Associated HotPTM clusters:
ALL:5677
,
ALL:5678
,
CPTAC:6462
,
CPTAC:6462.2
,
CPTAC:6462.3
PTM sites from various resources including CPTAC, PhosphoSitePlus and UniProtKB.
The TCGA PanCancer Atlas MC3 set is a collection of pancancer somatic mutations calls from all TCGA samples. More information can be found on MC3 project page.
COSMIC (the Catalogue Of Somatic Mutations In Cancer) is collection of somatic mutations in cancer with additional manual curation. More information can be found on COSMIC website.
(Only the canonical isoform P04626-1 is shown)
| Position | Residue | Category | PTM Type | Evidence (Manual/Automatic assertion) |
|---|---|---|---|---|
| 68 | N | Glycosylation | Glycosylation-N-linked-asparagine |
Manual assertion based on experiment [ECO:0000269]
Structural basis for high-affinity HER2 receptor binding by an engineered protein.
|
| 124 | N | Glycosylation | Glycosylation-N-linked-asparagine |
Manual assertion according to rules [ECO:0000255] |
| 150 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
|
| 175 | K | Methylation | N6,N6,N6-trimethyllysine |
Peer reviewed articles curated by PhosphoSitePlus®.
Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization
|
| 175 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
|
| 182 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 187 | N | Glycosylation | Glycosylation-N-linked-asparagine |
Manual assertion according to rules [ECO:0000255] |
| 196 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
|
| 259 | N | Glycosylation | Glycosylation-N-linked-asparagine |
Manual assertion based on experiment [ECO:0000269]
Structural basis for high-affinity HER2 receptor binding by an engineered protein.
Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site.
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
|
| 530 | N | Glycosylation | Glycosylation-N-linked-asparagine |
Manual assertion based on experiment [ECO:0000269]
Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site.
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]PDB: 1S78 |
| 571 | N | Glycosylation | Glycosylation-N-linked-asparagine |
Manual assertion based on experiment [ECO:0000269]
Structural basis for high-affinity HER2 receptor binding by an engineered protein.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]PDB: 3MZW |
| 573 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
|
| 575 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
|
| 629 | N | Glycosylation | Glycosylation-N-linked-asparagine |
Manual assertion according to rules [ECO:0000255] |
| 686 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation
The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling
Human Cancer Cells Exhibit Protein Kinase C-dependent c-erbB-2 Transmodulation That Correlates with Phosphatase Sensitivity and Kinase Activity
|
| 701 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma
Mechanisms for DNA‑damaging agent‑induced inactivation of ErbB2 and ErbB3 via the ERK and p38 signaling pathways
MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK-mediated HER2 phosphorylation at Thr701
Proteogenomics connects somatic mutations to signalling in breast cancer
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 703 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 716 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 716 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
|
| 724 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles
|
| 728 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
|
| 733 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Mass Spectrometry Mapping of Epidermal Growth Factor Receptor Phosphorylation Related to Oncogenic Mutations and Tyrosine Kinase Inhibitor Sensitivity
Quantitative Site-specific Phosphorylation Dynamics of Human Protein Kinases during Mitotic Progression
An Integrated Phosphoproteomics Work Flow Reveals Extensive Network Regulation in Early Lysophosphatidic Acid Signaling
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
|
| 735 | Y | Phosphorylation | Phosphotyrosine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors
Analysis of Phosphotyrosine Signaling in Glioblastoma Identifies STAT5 as a Novel Downstream Target of ΔEGFR
Mass Spectrometry Mapping of Epidermal Growth Factor Receptor Phosphorylation Related to Oncogenic Mutations and Tyrosine Kinase Inhibitor Sensitivity
Tyrosine Phosphorylation Profiling in FGF-2 Stimulated Human Embryonic Stem Cells
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS
Signaling networks assembled by oncogenic EGFR and c-Met
Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
Phosphotyrosine interactome of the ErbB‐receptor kinase family
|
| 736 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles
|
| 747 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Site-specific identification and quantitation of endogenous SUMO modifications under native conditions
Multiomic Analysis of the UV-Induced DNA Damage Response
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles
|
| 753 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
|
| 753 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles
|
| 759 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
|
| 762 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 765 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 772 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
|
| 819 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
|
| 831 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 854 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 860 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 875 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 877 | Y | Phosphorylation | Phosphotyrosine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Interaction of CDCP1 with HER2 Enhances HER2-Driven Tumorigenesis and Promotes Trastuzumab Resistance in Breast Cancer
Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics
Design optimization and characterization of Her2/neu-targeted immunotoxins: comparative in vitro and in vivo efficacy studies
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
Tyrosine Phosphorylation Profiling in FGF-2 Stimulated Human Embryonic Stem Cells
In-depth Analyses of Kinase-dependent Tyrosine Phosphoproteomes Based on Metal Ion-functionalized Soluble Nanopolymers
The Combination of Multiple Receptor Tyrosine Kinase Inhibitor and Mammalian Target of Rapamycin Inhibitor Overcomes Erlotinib Resistance in Lung Cancer Cell Lines through c-Met Inhibition
Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential
The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R
Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation
Signaling networks assembled by oncogenic EGFR and c-Met
Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling
Loss of Hsp90 Association Up-Regulates Src-Dependent ErbB2 Activity
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
Phosphoproteomic analysis of Her2/neu signaling and inhibition
Endogenous anti-HER2 antibodies block HER2 phosphorylation and signaling through extracellular signal-regulated kinase.
|
| 883 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Site-specific identification and quantitation of endogenous SUMO modifications under native conditions
|
| 887 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
|
| 900 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer
|
| 923 | Y | Phosphorylation | Phosphotyrosine |
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphotyrosine interactome of the ErbB‐receptor kinase family
|
| 937 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Site-specific identification and quantitation of endogenous SUMO modifications under native conditions
|
| 974 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
|
| 977 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
|
| 998 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells
|
| 1002 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1003 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1005 | Y | Phosphorylation | Phosphotyrosine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
Signaling networks assembled by oncogenic EGFR and c-Met
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
Phosphotyrosine interactome of the ErbB‐receptor kinase family
|
| 1007 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1023 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non–Small Cell Lung Cancer
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility
Signaling through ShcA Is Required for Transforming Growth Factor β- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion
Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling
Phosphotyrosine interactome of the ErbB‐receptor kinase family
Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer
Identification of autophosphorylation sites of HER2/neu.
|
| 1049 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
|
| 1050 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
|
| 1051 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
|
| 1052 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
|
| 1054 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Multiomic Analysis of the UV-Induced DNA Damage Response
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
An Informatics-assisted Label-free Quantitation Strategy that Depicts Phosphoproteomic Profiles in Lung Cancer Cell Invasion
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
Phosphoproteomic Analysis of Human Embryonic Stem Cells
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
A quantitative atlas of mitotic phosphorylation.
Quantitative comparison of IMAC and TiO2 surfaces used in the study of regulated, dynamic protein phosphorylation
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
A quantitative atlas of mitotic phosphorylation.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
|
| 1060 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Peer reviewed articles curated by PhosphoSitePlus®.
Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics
|
| 1066 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
|
| 1073 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
|
| 1078 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Manual assertion inferred from sequence similarity [ECO:0000250]UniProtKB: P06494 |
| 1083 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 1100 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
|
| 1103 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Peer reviewed articles curated by PhosphoSitePlus®.
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 1107 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Temporal Profiling of Lapatinib-suppressed Phosphorylation Signals in EGFR/HER2 Pathways
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
|
| 1112 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin‐dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways
Crystal structure and substrate specificity of PTPN12.
Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
Phosphotyrosine Signaling Networks in Epidermal Growth Factor Receptor Overexpressing Squamous Carcinoma Cells
Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.
Identification of autophosphorylation sites of HER2/neu.
Manual assertion based on experiment [ECO:0000269]
Crystal structure and substrate specificity of PTPN12.
|
| 1122 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1124 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1127 | Y | Phosphorylation | Phosphotyrosine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
|
| 1132 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1134 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
A quantitative atlas of mitotic phosphorylation.
|
| 1139 | Y | Phosphorylation | Phosphotyrosine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility
Signaling through ShcA Is Required for Transforming Growth Factor β- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
Muc4–ErbB2 Complex Formation and Signaling in Polarized CACO-2 Epithelial Cells Indicate That Muc4 Acts as an Unorthodox Ligand for ErbB2
Phosphotyrosine interactome of the ErbB‐receptor kinase family
Structural Basis for Dimerization of the Grb10 Src Homology 2 Domain
ErbB-2 Activates Stat3α in a Src- and JAK2-dependent Manner
Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer
Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.
Identification of autophosphorylation sites of HER2/neu.
Manual assertion based on experiment [ECO:0000269]
Crystal structure and substrate specificity of PTPN12.
|
| 1151 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Proteogenomics connects somatic mutations to signalling in breast cancer
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells
A quantitative atlas of mitotic phosphorylation.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
|
| 1166 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography
Proteogenomics connects somatic mutations to signalling in breast cancer
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 1172 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172.
|
| 1174 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 1177 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
|
| 1196 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin‐dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways
Crystal structure and substrate specificity of PTPN12.
Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain
AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility
Signaling through ShcA Is Required for Transforming Growth Factor β- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion
Phosphotyrosine interactome of the ErbB‐receptor kinase family
Memo mediates ErbB2-driven cell motility.
ErbB-2 Activates Stat3α in a Src- and JAK2-dependent Manner
Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer
Manual assertion based on experiment [ECO:0000269]
Crystal structure and substrate specificity of PTPN12.
|
| 1198 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1214 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1221 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin‐dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways
AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer
Design optimization and characterization of Her2/neu-targeted immunotoxins: comparative in vitro and in vivo efficacy studies
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition
Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
The Combination of Multiple Receptor Tyrosine Kinase Inhibitor and Mammalian Target of Rapamycin Inhibitor Overcomes Erlotinib Resistance in Lung Cancer Cell Lines through c-Met Inhibition
Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility
Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors
Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation
Signaling through ShcA Is Required for Transforming Growth Factor β- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion
Cdk5 Regulates STAT3 Activation and Cell Proliferation in Medullary Thyroid Carcinoma Cells
Endogenous anti-HER2 antibodies block HER2 phosphorylation and signaling through extracellular signal-regulated kinase.
ErbB-2 Activates Stat3α in a Src- and JAK2-dependent Manner
Identification of autophosphorylation sites of HER2/neu.
|
| 1222 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin‐dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways
AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer
Design optimization and characterization of Her2/neu-targeted immunotoxins: comparative in vitro and in vivo efficacy studies
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition
MEMO associated with an ErbB2 receptor phosphopeptide reveals a new phosphotyrosine motif
Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib
The Combination of Multiple Receptor Tyrosine Kinase Inhibitor and Mammalian Target of Rapamycin Inhibitor Overcomes Erlotinib Resistance in Lung Cancer Cell Lines through c-Met Inhibition
Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility
Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors
Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation
Signaling through ShcA Is Required for Transforming Growth Factor β- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion
Cdk5 Regulates STAT3 Activation and Cell Proliferation in Medullary Thyroid Carcinoma Cells
Phosphotyrosine interactome of the ErbB‐receptor kinase family
Memo mediates ErbB2-driven cell motility.
ErbB-2 Activates Stat3α in a Src- and JAK2-dependent Manner
Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer
The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling
Adjacent Carboxyterminal Tyrosine Phosphorylation Events Identify Functionally Distinct ErbB2 Receptor Subsets: Implications for Molecular Diagnostics
Identification of autophosphorylation sites of HER2/neu.
|
| 1235 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1236 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1240 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
|
| 1242 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1248 | Y | Phosphorylation | Phosphotyrosine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin‐dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways
Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization
PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2
Proteogenomics connects somatic mutations to signalling in breast cancer
Crystal structure and substrate specificity of PTPN12.
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines
Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain
Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells
AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer
Interaction of CDCP1 with HER2 Enhances HER2-Driven Tumorigenesis and Promotes Trastuzumab Resistance in Breast Cancer
Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial–mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Development of a 5-plex SILAC Method Tuned for the Quantitation of Tyrosine Phosphorylation Dynamics
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification
Quantitative Phospho-Proteomic Profiling of Hepatocyte Growth Factor (HGF)-MET Signaling in Colorectal Cancer
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
Phosphoproteomic Analysis of Signaling Pathways in Head and Neck Squamous Cell Carcinoma Patient Samples
Survey of Activated FLT3 Signaling in Leukemia
Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth.
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
Copine-III interacts with ErbB2 and promotes tumor cell migration.
Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor α and its phosphorylation at serine 305
c-Src Associates with ErbB2 through an Interaction between Catalytic Domains and Confers Enhanced Transforming Potential
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility
Protein Kinase A-mediated Gating of Neuregulin-dependent ErbB2-ErbB3 Activation Underlies the Synergistic Action of cAMP on Schwann Cell Proliferation
Laser Capture Microdissection and Protein Microarray Analysis of Human Non-small Cell Lung Cancer
Signaling through ShcA Is Required for Transforming Growth Factor β- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion
Signaling networks assembled by oncogenic EGFR and c-Met
Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivoanalysis
ERBB2 phosphorylation and trastuzumab sensitivity of breast cancer cell lines
Quantitative comparison of IMAC and TiO2 surfaces used in the study of regulated, dynamic protein phosphorylation
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks
Cdk5 Regulates STAT3 Activation and Cell Proliferation in Medullary Thyroid Carcinoma Cells
Lapatinib Antitumor Activity Is Not Dependent upon Phosphatase and Tensin Homologue Deleted on Chromosome 10 in ErbB2-Overexpressing Breast Cancers
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration
Muc4–ErbB2 Complex Formation and Signaling in Polarized CACO-2 Epithelial Cells Indicate That Muc4 Acts as an Unorthodox Ligand for ErbB2
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
Loss of Hsp90 Association Up-Regulates Src-Dependent ErbB2 Activity
Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Endogenous anti-HER2 antibodies block HER2 phosphorylation and signaling through extracellular signal-regulated kinase.
Phosphotyrosine interactome of the ErbB‐receptor kinase family
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.
Muc4/Sialomucin Complex, the Intramembrane ErbB2 Ligand, Translocates ErbB2 to the Apical Surface in Polarized Epithelial Cells
Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c‐erbB‐2 receptor via epidermal growth factor receptor
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27kip, but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways
ErbB-2 Activates Stat3α in a Src- and JAK2-dependent Manner
Phosphorylation on Tyrosine-15 of p34Cdc2 by ErbB2 Inhibits p34Cdc2 Activation and Is Involved in Resistance to Taxol-Induced Apoptosis
Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer
Prognostic and Predictive Significance of ErbB-2 Breast Tumor Levels Measured by Enzyme Immunoassay
Adjacent Carboxyterminal Tyrosine Phosphorylation Events Identify Functionally Distinct ErbB2 Receptor Subsets: Implications for Molecular Diagnostics
Identification of autophosphorylation sites of HER2/neu.
Manual assertion based on experiment [ECO:0000269]
Crystal structure and substrate specificity of PTPN12.
Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
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