Example: HER2, histone, P28482, P19174-2

Protein SPI1_HUMAN (P17947)

Canonical isoform: P17947-1 [UniProt]

Other possible isoforms:
P17947-2

HUGO gene symbols:

Protein name: Transcription factor PU.1

Associated HotPTM clusters:

PTM sites

(Only the canonical isoform P17947-1 is shown)

Position Residue Category PTM Type Evidence (Manual/Automatic assertion)
17 S Phosphorylation Phosphoserine
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
  • Curation set 12496 (2011)
41 S Phosphorylation Phosphoserine
Peer reviewed articles curated by PhosphoSitePlus®.

FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1
Mishra Mukul, Thacker Gatha, Sharma Akshay et al.
Molecular Cancer Research 19:261-273 (2020). [PubMed] [Europe PMC]

140 S Phosphorylation Phosphoserine
Peer reviewed articles curated by PhosphoSitePlus®.

FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1
Mishra Mukul, Thacker Gatha, Sharma Akshay et al.
Molecular Cancer Research 19:261-273 (2020). [PubMed] [Europe PMC]

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Bian Y., Song C., Cheng K. et al.
J. Proteomics 96:253-262 (2014). [PubMed] [Europe PMC]

Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Bian Y., Song C., Cheng K. et al.
J. Proteomics 96:253-262 (2014). [PubMed] [Europe PMC]

146 S Phosphorylation Phosphoserine
Mass spectrometry data [ECO:0007829]

From CPTAC2 BRCA prospective

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
Krug Karsten, Jaehnig Eric J., Satpathy Shankha et al.
Cell 183:1436-1456.e31 (2020). [PubMed] [Europe PMC]

From CPTAC3 LUAD discovery

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Gillette Michael A., Satpathy Shankha, Cao Song et al.
Cell 182:200-225.e35 (2020). [PubMed] [Europe PMC]

From CPTAC3 UCEC discovery

Proteogenomic Characterization of Endometrial Carcinoma
Dou Yongchao, Kawaler Emily A., Cui Zhou Daniel et al.
Cell 180:729-748.e26 (2020). [PubMed] [Europe PMC]

From CPTAC3 LSCC discovery

Unpublished data

Peer reviewed articles curated by PhosphoSitePlus®.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Bian Y., Song C., Cheng K. et al.
J. Proteomics 96:253-262 (2014). [PubMed] [Europe PMC]

Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Bian Y., Song C., Cheng K. et al.
J. Proteomics 96:253-262 (2014). [PubMed] [Europe PMC]

253 S Phosphorylation Phosphoserine
Mass spectrometry data [ECO:0007829]

From CPTAC2 BRCA prospective

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
Krug Karsten, Jaehnig Eric J., Satpathy Shankha et al.
Cell 183:1436-1456.e31 (2020). [PubMed] [Europe PMC]

Peer reviewed articles curated by PhosphoSitePlus®.

Proteogenomics connects somatic mutations to signalling in breast cancer
Mertins Philipp, NCI CPTAC, Mani D. R. et al.
Nature 534:55-62 (2016). [PubMed] [Europe PMC]