Canonical isoform: Q15788-1 [UniProt]
Other possible isoforms:
Q15788-2,
Q15788-3
HUGO gene symbols:
Protein name: Nuclear receptor coactivator 1
Associated HotPTM clusters:
PTM sites from various resources including CPTAC, PhosphoSitePlus and UniProtKB.
The TCGA PanCancer Atlas MC3 set is a collection of pancancer somatic mutations calls from all TCGA samples. More information can be found on MC3 project page.
COSMIC (the Catalogue Of Somatic Mutations In Cancer) is collection of somatic mutations in cancer with additional manual curation. More information can be found on COSMIC website.
(Only the canonical isoform Q15788-1 is shown)
| Position | Residue | Category | PTM Type | Evidence (Manual/Automatic assertion) |
|---|---|---|---|---|
| 2 | S | Acetylation | N-acetylserine |
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
|
| 9 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 LSCC discovery Unpublished data |
| 22 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Multiomic Analysis of the UV-Induced DNA Damage Response
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Quantification of Pancreatic Cancer Proteome and Phosphorylome: Indicates Molecular Events Likely Contributing to Cancer and Activity of Drug Targets
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors
Integrated proteomic analysis of post-translational modifications by serial enrichment
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 26 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
In-depth Analyses of Kinase-dependent Tyrosine Phosphoproteomes Based on Metal Ion-functionalized Soluble Nanopolymers
|
| 29 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
|
| 30 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 81 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 88 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
|
| 89 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
|
| 90 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
|
| 96 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 103 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
|
| 209 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
|
| 271 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
|
| 274 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 277 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 308 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
|
| 325 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 369 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 372 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Integrated proteomic analysis of post-translational modifications by serial enrichment
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
Manual assertion based on experiment [ECO:0000269]
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 389 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
|
| 393 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells
|
| 395 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Proteogenomics connects somatic mutations to signalling in breast cancer
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Integrated proteomic analysis of post-translational modifications by serial enrichment
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
Manual assertion based on experiment [ECO:0000269]
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
|
| 423 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 488 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 517 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
Manual assertion based on experiment [ECO:0000269]
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
|
| 558 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Manual assertion inferred from sequence similarity [ECO:0000250]UniProtKB: P70365 |
| 565 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 566 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 569 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
Manual assertion based on experiment [ECO:0000269]
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
|
| 571 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 LSCC discovery Unpublished data |
| 579 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 LSCC discovery Unpublished data |
| 582 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 598 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
|
| 620 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
|
| 625 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
|
| 632 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
|
| 659 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
|
| 698 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 700 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
|
| 704 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
|
| 711 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LSCC discovery Unpublished data |
| 732 | K | Sumoylation | Sumoylated_lysine |
Peer reviewed articles curated by PhosphoSitePlus®.
Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.
|
| 755 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
|
| 758 | K | Acetylation | N6-acetyllysine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LSCC discovery Unpublished data |
| 763 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From CPTAC3 LSCC discovery Unpublished data |
| 774 | K | Sumoylation | Sumoylated_lysine |
Peer reviewed articles curated by PhosphoSitePlus®.
Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.
|
| 789 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 853 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
|
| 856 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
|
| 863 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
MHC Class I-Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia
|
| 959 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Integrated proteomic analysis of post-translational modifications by serial enrichment
|
| 979 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 997 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 999 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From CPTAC3 LSCC discovery Unpublished data |
| 1001 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
|
| 1006 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 1026 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 1029 | R | Methylation | Dimethylated_arginine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1033 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
Manual assertion based on experiment [ECO:0000269]
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
|
| 1041 | R | Methylation | Dimethylated_arginine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1073 | R | Methylation | Asymmetric_dimethylarginine |
Manual assertion inferred from sequence similarity [ECO:0000250]UniProtKB: P70365 |
| 1091 | R | Methylation | Asymmetric_dimethylarginine |
Manual assertion inferred from sequence similarity [ECO:0000250]UniProtKB: P70365 |
| 1114 | R | Methylation | Omega-N-methylarginine |
Peer reviewed articles curated by PhosphoSitePlus®.
Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells
|
| 1124 | R | Methylation | Asymmetric_dimethylarginine |
Manual assertion inferred from sequence similarity [ECO:0000250]UniProtKB: P70365 |
| 1131 | R | Methylation | Dimethylated_arginine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
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| 1131 | R | Methylation | Asymmetric_dimethylarginine |
Manual assertion inferred from sequence similarity [ECO:0000250]UniProtKB: P70365 |
| 1179 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
Ligand-independent Activation of the Androgen Receptor by Interleukin-6 and the Role of Steroid Receptor Coactivator-1 in Prostate Cancer Cells
8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
Manual assertion based on experiment [ECO:0000269]
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
|
| 1185 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
Ligand-independent Activation of the Androgen Receptor by Interleukin-6 and the Role of Steroid Receptor Coactivator-1 in Prostate Cancer Cells
8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
Manual assertion based on experiment [ECO:0000269]
Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.
|
| 1250 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 1271 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 1279 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|
| 1372 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
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| 1373 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
|
| 1426 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
Peer reviewed articles curated by PhosphoSitePlus®.
Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus
|