Canonical isoform: Q9BX63-1 [UniProt]
Other possible isoforms:
Q9BX63-2
HUGO gene symbols:
Protein name: Fanconi anemia group J protein
Associated HotPTM clusters:
PTM sites from various resources including CPTAC, PhosphoSitePlus and UniProtKB.
The TCGA PanCancer Atlas MC3 set is a collection of pancancer somatic mutations calls from all TCGA samples. More information can be found on MC3 project page.
COSMIC (the Catalogue Of Somatic Mutations In Cancer) is collection of somatic mutations in cancer with additional manual curation. More information can be found on COSMIC website.
(Only the canonical isoform Q9BX63-1 is shown)
| Position | Residue | Category | PTM Type | Evidence (Manual/Automatic assertion) |
|---|---|---|---|---|
| 22 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 39 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Integrated proteomic analysis of post-translational modifications by serial enrichment
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 77 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
|
| 110 | Y | Phosphorylation | Phosphotyrosine |
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors
|
| 112 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors
Global phosphorylation analysis of -arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
|
| 113 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Integrated proteomic analysis of post-translational modifications by serial enrichment
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Survey of Activated FLT3 Signaling in Leukemia
CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
|
| 116 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors
|
| 124 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 128 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Integrated proteomic analysis of post-translational modifications by serial enrichment
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 132 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
|
| 137 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 139 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Integrated proteomic analysis of post-translational modifications by serial enrichment
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 142 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Integrated proteomic analysis of post-translational modifications by serial enrichment
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 158 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 186 | K | Acetylation | N6-acetyllysine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 191 | K | Acetylation | N6-acetyllysine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 197 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Quantitative Phospho-proteomics to Investigate the Polo-like Kinase 1-Dependent Phospho-proteome
|
| 204 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 206 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Multiomic Analysis of the UV-Induced DNA Damage Response
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1
Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells
Integrated proteomic analysis of post-translational modifications by serial enrichment
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
|
| 222 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 226 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
|
| 229 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 230 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 232 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 254 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Integrated proteomic analysis of post-translational modifications by serial enrichment
|
| 274 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 278 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 297 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Integrated proteomic analysis of post-translational modifications by serial enrichment
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 345 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
|
| 348 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 461 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 503 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 505 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Integrated proteomic analysis of post-translational modifications by serial enrichment
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 508 | Y | Phosphorylation | Phosphotyrosine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 510 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 584 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
|
| 656 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 742 | Y | Phosphorylation | Phosphotyrosine |
Peer reviewed articles curated by PhosphoSitePlus®.
Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells
|
| 747 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Integrated proteomic analysis of post-translational modifications by serial enrichment
|
| 764 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Integrated proteomic analysis of post-translational modifications by serial enrichment
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
|
| 797 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Multiomic Analysis of the UV-Induced DNA Damage Response
Integrated proteomic analysis of post-translational modifications by serial enrichment
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
|
| 862 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles
|
| 895 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Integrated proteomic analysis of post-translational modifications by serial enrichment
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 897 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 916 | Y | Phosphorylation | Phosphotyrosine |
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
A quantitative atlas of mitotic phosphorylation.
|
| 918 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Integrated proteomic analysis of post-translational modifications by serial enrichment
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
A quantitative atlas of mitotic phosphorylation.
|
| 921 | Y | Phosphorylation | Phosphotyrosine |
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
A quantitative atlas of mitotic phosphorylation.
|
| 927 | S | Phosphorylation | Phosphoserine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
A quantitative atlas of mitotic phosphorylation.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
A quantitative atlas of mitotic phosphorylation.
|
| 930 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Integrated proteomic analysis of post-translational modifications by serial enrichment
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
A quantitative atlas of mitotic phosphorylation.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
A quantitative atlas of mitotic phosphorylation.
|
| 953 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 954 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
Integrated proteomic analysis of post-translational modifications by serial enrichment
Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments
|
| 956 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels
Integrated proteomic analysis of post-translational modifications by serial enrichment
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 964 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 LSCC discovery Unpublished data |
| 982 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 988 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 989 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
From CPTAC3 LSCC discovery Unpublished data |
| 990 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
Peer reviewed articles curated by PhosphoSitePlus®.
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.
Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
Targeting the FANCJ–BRCA1 interaction promotes a switch from recombination to polη-dependent bypass
A quantitative atlas of mitotic phosphorylation.
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains.
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
The BRCT domain is a phospho-protein binding domain.
Manual assertion based on experiment [ECO:0000269]
The BRCT domain is a phospho-protein binding domain.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
A quantitative atlas of mitotic phosphorylation.
|
| 1001 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Integrated proteomic analysis of post-translational modifications by serial enrichment
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 1003 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 1004 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Integrated proteomic analysis of post-translational modifications by serial enrichment
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
|
| 1007 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1020 | T | Phosphorylation | Phosphothreonine |
Peer reviewed articles curated by PhosphoSitePlus®.
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 1026 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From TCGA BRCA retrospective
Proteogenomics connects somatic mutations to signalling in breast cancer
|
| 1031 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
|
| 1032 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 LSCC discovery Unpublished data Peer reviewed articles curated by PhosphoSitePlus®.
Multiomic Analysis of the UV-Induced DNA Damage Response
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells*
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Integrated proteomic analysis of post-translational modifications by serial enrichment
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
|
| 1045 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1050 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1063 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 1133 | T | Phosphorylation | Phosphothreonine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control
|
| 1142 | T | Phosphorylation | Phosphothreonine |
Mass spectrometry data [ECO:0007829]From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1162 | S | Phosphorylation | Phosphoserine |
Peer reviewed articles curated by PhosphoSitePlus®.
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Integrated proteomic analysis of post-translational modifications by serial enrichment
Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells
|
| 1168 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 1168 | K | Acetylation | N6-acetyllysine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
|
| 1186 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Mass spectrometry data [ECO:0007829]From CPTAC3 LSCC discovery Unpublished data |
| 1214 | K | Ubiquitination | Ubiquitination-Lys-Gly |
Peer reviewed articles curated by PhosphoSitePlus®.
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
|
| 1237 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC3 GBM discovery
Proteogenomic and metabolomic characterization of human glioblastoma
From CPTAC3 HNSCC discovery
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
From CPTAC2 OV prospective
Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability
From CPTAC3 UCEC discovery
Proteogenomic Characterization of Endometrial Carcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 CCRCC discovery
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Proteogenomics connects somatic mutations to signalling in breast cancer
Multiomic Analysis of the UV-Induced DNA Damage Response
Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors
Integrated proteomic analysis of post-translational modifications by serial enrichment
Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project
Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics*
Manual assertion inferred from algorithms based on publications or databases entries, e.g., large-scale proteomics data and 3D structure [ECO:0007744]
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
|
| 1239 | S | Phosphorylation | Phosphoserine |
Mass spectrometry data [ECO:0007829]From CPTAC2 BRCA prospective
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
From CPTAC3 LUAD discovery
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
From CPTAC2 CRC prospective
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities
From CPTAC3 LSCC discovery Unpublished data Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1
|
| 1249 | K | Acetylation | N6-acetyllysine |
Cell Signaling Technology® internal validation data by PhosphoSitePlus®.
Peer reviewed articles curated by PhosphoSitePlus®.
FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.
Manual assertion based on experiment [ECO:0000269]
FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.
|